Institute of Pharmacology, Polish Academy of Sciences, Department of Behavioral Neuroscience and Drug Development, Kraków, Poland.
Pharmacol Rep. 2018 Aug;70(4):639-649. doi: 10.1016/j.pharep.2018.01.009. Epub 2018 Feb 2.
Impaired cognitive functioning is recognized as an integral feature of schizophrenia. These deficits have emerged not only as an important predictor of clinical and social outcomes but also as a target for schizophrenia therapeutics. Several cognitive functions have been identified as being commonly deficient in schizophrenia patients, including attention, working memory, reasoning and problem solving, visual learning and memory or social cognition. The selected neuropsychological tests measuring these specific domains were included in the MATRICS Consensus Cognitive Battery (MCCB) and in the Cambridge Neuropsychological Test Automated Battery (CANTAB). While the MCCB and the CANTAB are used in clinical trials of cognition-enhancing drugs for schizophrenia, there is a growing need for a translational test battery that can be used in animal models. To reduce the translational gap between preclinical and clinical studies, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CINTRICS) programme has recommended animal tasks with construct validity for the evaluation of cognitive domains that are affected in schizophrenia. This review will overview rodent tests that are widely used to identify schizophrenia-like cognitive impairments, including CINTRICS's recommendations and novel touchscreen-based procedures.
认知功能障碍被认为是精神分裂症的一个固有特征。这些缺陷不仅是临床和社会结局的重要预测指标，也是精神分裂症治疗的靶点。已经确定了几种认知功能在精神分裂症患者中普遍存在缺陷，包括注意力、工作记忆、推理和解决问题、视觉学习和记忆或社会认知。用于测量这些特定领域的特定神经心理学测试被纳入了 MATRICS 共识认知电池（MCCB）和剑桥神经心理学测试自动化电池（CANTAB）。虽然 MCCB 和 CANTAB 用于精神分裂症认知增强药物的临床试验，但越来越需要一种可用于动物模型的转化测试电池。为了减少临床前和临床研究之间的转化差距，认知神经科学治疗研究以改善精神分裂症认知（CINTRICS）计划推荐了具有构念效度的动物任务，用于评估受精神分裂症影响的认知领域。这篇综述将概述广泛用于识别类似精神分裂症认知障碍的啮齿动物测试，包括 CINTRICS 的建议和新的基于触摸屏的程序。
