Stasikowska-Kanicka Olga, Wągrowska-Danilewicz Małgorzata, Kulicka Paulina, Danilewicz Marian
Pol J Pathol. 2018;69(1):67-72. doi: 10.5114/pjp.2018.75339.
ADAMs (a disintegrin and metalloproteinase) are important mediators of cell signalling events, which play a role in the pathogenesis and progression of cancers. Immunohistochemical method was used to examine the immunoexpression of ADAM10 and microvessel density in 80 cases of oral squamous cell carcinoma (OSCC): without metastases - OSCC M(-) (n = 38), and with metastases - OSCC M(+) (n = 42), in 24 cases of oral leukoplakia (OLK), (15 cases with low-grade dysplasia - OLK-LG, and 9 cases with high-grade dysplasia - OLK-HG), and 19 controls. The immunoexpression of ADAM10 and the mean number of vessels were significantly increased in both groups of OSCC in comparison to both groups of OLK and controls. Moreover, the immunoexpression of ADAM10 and microvessel density were significantly increased in the OSCC M(+) group in comparison to the OSCC M(-) group. No statistically significant differences were found between immunoexpression of ADAM10 and microvessels density in the OLK-LG, OLK-HG, and control cases. In conclusion, the present study revealed overexpression of ADAM10 in OSCCs, especially in OSCC with metastasis. These findings suggest that ADAM10 could potentially contribute to metastases of oral cancer. Although, our findings suggest that ADAM10 may be involved in angiogenesis of OSCC, further studies are required to determine the role of ADAM10 in this process.
解聚素和金属蛋白酶（ADAMs）是细胞信号转导事件的重要介质，在癌症的发病机制和进展中发挥作用。采用免疫组织化学方法检测80例口腔鳞状细胞癌（OSCC）中ADAM10的免疫表达和微血管密度：无转移的OSCC M(-)（n = 38），有转移的OSCC M(+)（n = 42），24例口腔白斑（OLK）（15例低级别发育异常 - OLK-LG，9例高级别发育异常 - OLK-HG），以及19例对照。与OLK组和对照组相比，两组OSCC中ADAM10的免疫表达和血管平均数均显著增加。此外，与OSCC M(-)组相比，OSCC M(+)组中ADAM10的免疫表达和微血管密度显著增加。在OLK-LG、OLK-HG和对照病例中，ADAM10的免疫表达和微血管密度之间未发现统计学上的显著差异。总之，本研究揭示了ADAM10在OSCC中过表达，尤其是在有转移的OSCC中。这些发现表明ADAM10可能对口腔癌转移有潜在作用。虽然我们的发现提示ADAM10可能参与OSCC的血管生成，但需要进一步研究来确定ADAM10在此过程中的作用。
