Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany.
Cardiovasc Diabetol. 2018 Jun 12;17(1):88. doi: 10.1186/s12933-018-0721-0.
Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states.
Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI. Measures of abdominal adiposity such as hepatic proton-density fat fraction [PDFF], subcutaneous (SAT) and visceral abdominal fat (VAT) as well as established cardiac left-ventricular (LV) measures including LV remodeling index (LVCI) were derived. Associations were determined using linear regression analysis based on standard deviation normalized predictors.
Among a total of 374 subjects (56.2 ± 9.1 years, 58% males), 49 subjects had diabetes, 99 subjects had prediabetes and 226 represented normal controls. Only subtle cardiac alterations were observed (e.g. LVCI: 1.13 ± 0.30). While SAT was not associated, increasing VAT and increasing PDFF were independently associated with increasing LVCI (β = 0.11 and 0.06, respectively), decreasing LV end-diastolic volume (β = - 6.70 and 3.23, respectively), and decreasing LV stroke volume (β = - 3.91 and - 2.20, respectively). Hyperglycemic state did not modify the associations between VAT or PDFF and LV measures (interaction term: all p ≥ 0.29).
In a healthy population, VAT but also PDFF were associated with subclinical measures of LV remodeling without evidence for a modifying effect of hyperglycemic state.
局部腹部脂肪沉积可能与心脏功能和形态的改变有关，这是一种代谢关联。因此，我们旨在确定它们与细微的心脏变化的关联，以及与高血糖代谢状态的潜在相互作用。
从奥格斯堡合作健康研究地区的 FF4 队列中抽取无心血管疾病史的一般人群作为研究对象，并进行 3T 心脏和身体 MRI 检查。测量腹部脂肪的指标，如肝质子密度脂肪分数[PDFF]、皮下（SAT）和内脏腹部脂肪（VAT），以及已建立的心脏左心室（LV）指标，包括 LV 重构指数（LVCI）。采用基于标准偏差归一化预测因子的线性回归分析来确定相关性。
在总共 374 名受试者（56.2±9.1 岁，58%为男性）中，49 名患有糖尿病，99 名患有前驱糖尿病，226 名代表正常对照组。仅观察到细微的心脏改变（例如，LVCI：1.13±0.30）。虽然 SAT 没有相关性，但 VAT 的增加和 PDFF 的增加与 LVCI 的增加独立相关（β分别为 0.11 和 0.06），LV 舒张末期容积的减少（β分别为-6.70 和 3.23），以及 LV 收缩期容积的减少（β分别为-3.91 和-2.20）。高血糖状态并没有改变 VAT 或 PDFF 与 LV 测量之间的关联（交互项：所有 p≥0.29）。
在健康人群中，VAT 但 PDFF 也与 LV 重构的亚临床指标相关，没有证据表明高血糖状态有修饰作用。
