一种存在于缺陷型单纯疱疹病毒基因组中的新型美国-a连接区的核苷酸序列和结构特征。
Nucleotide sequence and structural features of a novel US-a junction present in a defective herpes simplex virus genome.
作者信息
Mocarski E S, Deiss L P, Frenkel N
出版信息
J Virol. 1985 Jul;55(1):140-6. doi: 10.1128/JVI.55.1.140-146.1985.
Abstract
Defective genomes generated during serial propagation of herpes simplex virus type 1 (Justin) consist of tandem reiterations of sequences that are colinear with a portion of the S component of the standard viral genome. We determined the structure of the novel US-a junction, at which the US sequences of one repeat unit join the a sequences of the adjacent repeat unit. Comparison of the nucleotide sequence at this junction with the nucleotide sequence of the corresponding US region of the standard virus genome indicated that the defective genome repeat unit arose by a single recombinational event between an L-S junction a sequence and the US region. The recombinational process might have been mediated by limited sequence homology. The sequences retained within the US-a junction further define the signal for cleavage and packaging of viral DNA.
摘要
在单纯疱疹病毒1型（贾斯汀株）连续传代过程中产生的缺陷基因组由与标准病毒基因组S组分的一部分共线的序列串联重复组成。我们确定了新型US-a连接点的结构，一个重复单元的US序列在此处与相邻重复单元的a序列相连。将此连接点的核苷酸序列与标准病毒基因组相应US区域的核苷酸序列进行比较表明，缺陷基因组重复单元是由L-S连接点a序列与US区域之间的单个重组事件产生的。重组过程可能由有限的序列同源性介导。保留在US-a连接点内的序列进一步确定了病毒DNA切割和包装的信号。
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