Mishra Pallav, Lal Ajay, Mohindra Mukul, Mehta Nitin, Joshi Deepak, Chaudhary Deepak
Sports Injury Center, V M. Medical College and Associated Safdarjung Hospital, New Delhi, India.
J Clin Orthop Trauma. 2018 Apr-Jun;9(2):167-171. doi: 10.1016/j.jcot.2017.09.017. Epub 2017 Sep 29.
Post-operative infection is a dreadful complication of ACL reconstruction with gray zone over management guidelines. We aimed to establish commonest etiology, assess incidence of infection and effect on outcome, individually for single and double bundle ACL reconstruction techniques, so as to formulate appropriate management guidelines.
Our prospective study involved 1152 patients operated for ACL reconstruction (437- DBACL, 715- SBACL) from 2010-2013. Post-operative infection was diagnosed clinically supported by positive gram stain/ culture and increased cell count in knee aspirate. All patients were started on empirical antibiotics and arthroscopic lavage and debridement was done. Graft was retained if it was stable and intact. Data recorded at follow up was analysed statistically.
In SBACL infection rate was 0.84% while in DBACL it was 2.52%. All patients with infection presented with pain, effusion, fever and increased WBC, ESR & CRP. Average time of presentation after the surgery was 2.27 weeks for DBACL and 2.16 weeks for SBACL. In both groups, S.aureus followed by S. epidermidis were commonest isolates. Patients were given IV antibiotics for 2 weeks and oral for further 4 weeks.
Incidence of infection is higher with the double bundle technique, however, the functional outcome is not affected (p value 0.231). Joint aspirate is the gold standard diagnostic test for infection. CRP and ESR are the next dependable tests with high sensitivity but their specificity is low. A thorough debridement is necessary apart from recommended antibiotic cover of 2 weeks IV followed by 4 weeks oral antibiotics.
术后感染是前交叉韧带重建术后一种可怕的并发症,管理指南存在灰色地带。我们旨在确定最常见的病因,评估感染发生率及其对手术效果的影响,分别针对单束和双束前交叉韧带重建技术,从而制定合适的管理指南。
我们的前瞻性研究纳入了2010年至2013年期间接受前交叉韧带重建手术的1152例患者(437例采用双束前交叉韧带重建,715例采用单束前交叉韧带重建)。术后感染通过临床诊断,革兰氏染色/培养阳性及膝关节穿刺液中细胞计数增加予以支持。所有患者均开始经验性使用抗生素,并进行关节镜冲洗和清创。如果移植物稳定且完整,则予以保留。对随访记录的数据进行统计学分析。
单束前交叉韧带重建的感染率为0.84%,而双束前交叉韧带重建的感染率为2.52%。所有感染患者均出现疼痛、积液、发热以及白细胞、血沉和C反应蛋白升高。双束前交叉韧带重建术后出现感染症状的平均时间为2.27周,单束前交叉韧带重建为2.16周。在两组中,最常见的分离菌是金黄色葡萄球菌,其次是表皮葡萄球菌。患者接受了2周的静脉抗生素治疗,之后继续口服抗生素4周。
双束技术的感染发生率较高,然而,功能结果不受影响(p值为0.231)。关节穿刺液是感染的金标准诊断测试。血沉和C反应蛋白是接下来可靠性较高的测试,敏感性高但特异性低。除了推荐的2周静脉抗生素治疗及随后4周口服抗生素外,彻底清创也是必要的。