Jarc Eva, Eichmann Thomas O, Zimmermann Robert, Petan Toni
Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia.
Jožef Stefan International Postgraduate School, Ljubljana, Slovenia.
Data Brief. 2018 Mar 12;18:234-240. doi: 10.1016/j.dib.2018.03.033. eCollection 2018 Jun.
The data presented here is related to the research article entitled "Lipid droplets induced by secreted phospholipase A and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress" by E. Jarc et al., Biochim. Biophys. Acta 1863 (2018) 247-265. Elevated uptake of unsaturated fatty acids and lipid droplet accumulation are characteristic of aggressive cancer cells and have been associated with the cellular stress response. The present study provides lipidomic data on the triacylglycerol (TAG) and phosphatidylcholine (PC) composition of MDA-MB-231 breast cancer cells exposed to docosahexaenoic acid (DHA; 22:6, ω-3). Datasets provide information on the changes in lipid composition induced by depletion of adipose triglyceride lipase (ATGL) and by exogenous addition of secreted phospholipase A (sPLA) in DHA-treated cells. The presented alterations in lipid composition, mediated by targeting lipid droplet biogenesis and lipolysis, are associated with protection from lipotoxicity and allow further investigation into the role of lipid droplets in the resistance of cancer cells to lipotoxic stress.
此处呈现的数据与E. Jarc等人发表的题为《分泌型磷脂酶A和不饱和脂肪酸诱导的脂滴保护乳腺癌细胞免受营养和脂毒性应激》的研究文章相关，该文章发表于《生物化学与生物物理学报》1863卷（2018年）第247 - 265页。不饱和脂肪酸摄取增加和脂滴积累是侵袭性癌细胞的特征，并且与细胞应激反应相关。本研究提供了关于暴露于二十二碳六烯酸（DHA；22:6，ω - 3）的MDA - MB - 231乳腺癌细胞中三酰甘油（TAG）和磷脂酰胆碱（PC）组成的脂质组学数据。数据集提供了有关在DHA处理的细胞中，脂肪甘油三酯脂肪酶（ATGL）缺失以及外源添加分泌型磷脂酶A（sPLA）所诱导的脂质组成变化的信息。通过靶向脂滴生物合成和脂解介导的脂质组成变化与免受脂毒性保护相关，并有助于进一步研究脂滴在癌细胞抵抗脂毒性应激中的作用。
