与 KSHV 相关肿瘤相关的信号转导通路。

Signal Transduction Pathways Associated with KSHV-Related Tumors.

机构信息

Department of Cell Biology, Kyoto Pharmaceutical University, Kyoto, Japan.

出版信息

Adv Exp Med Biol. 2018;1045:321-355. doi: 10.1007/978-981-10-7230-7_15.

Abstract

Signal transduction pathways play a key role in the regulation of cell growth, cell differentiation, cell survival, apoptosis, and immune responses. Bacterial and viral pathogens utilize the cell signal pathways by encoding their own proteins or noncoding RNAs to serve their survival and replication in infected cells. Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is classified as a rhadinovirus in the γ-herpesvirus subfamily and was the eighth human herpesvirus to be discovered from Kaposi's sarcoma specimens. KSHV is closely associated with an endothelial cell malignancy, Kaposi's sarcoma, and B-cell malignancies, primary effusion lymphoma, and multicentric Castleman's disease. Recent studies have revealed that KSHV manipulates the cellular signaling pathways to achieve persistent infection, viral replication, cell proliferation, anti-apoptosis, and evasion of immune surveillance in infected cells. This chapter summarizes recent developments in our understanding of the molecular mechanisms used by KSHV to interact with the cell signaling machinery.

摘要

信号转导通路在细胞生长、细胞分化、细胞存活、细胞凋亡和免疫反应的调控中发挥着关键作用。细菌和病毒病原体通过编码自身的蛋白质或非编码 RNA 来利用细胞信号通路，以在感染的细胞中生存和复制。卡波济肉瘤相关疱疹病毒（Kaposi's sarcoma-associated herpesvirus，KSHV），也称为人类疱疹病毒 8（human herpesvirus 8，HHV-8），属于γ疱疹病毒亚科的 rhadinovirus，是从卡波济肉瘤标本中发现的第八种人类疱疹病毒。KSHV 与内皮细胞恶性肿瘤卡波济肉瘤以及 B 细胞恶性肿瘤、原发性渗出性淋巴瘤和多中心卡斯特曼病密切相关。最近的研究表明，KSHV 操纵细胞信号通路，以在感染细胞中实现持续感染、病毒复制、细胞增殖、抗细胞凋亡和逃避免疫监视。本章总结了我们对 KSHV 与细胞信号机制相互作用的分子机制的最新理解。