Li Tingting, Gao Shou-Jiang
Cancer Virology Program, UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Cell Biosci. 2021 Sep 27;11(1):176. doi: 10.1186/s13578-021-00688-0.
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus associated with several human cancers. KSHV infection and KSHV-induced anabolic cell proliferation and cellular transformation depend on reprogramming of cellular metabolic pathways, which provide the building blocks and energy for the growth of both the virus and the infected cells. Furthermore, KSHV dysregulates numerous metabolic sensors including mTOR, AMPK, CASTOR1 and sirtuins to maintain cellular energetic homeostasis during infection and in KSHV-induced cancers. In this review, we summarize the recent advances in the understanding of KSHV hijacking of metabolic pathways and sensors, providing insights into the molecular basis of KSHV infection and KSHV-induced oncogenesis. In addition, we highlight the critical metabolic targets and sensors for developing potential new therapies against KSHV infection and KSHV-induced cancers.
卡波西肉瘤相关疱疹病毒（KSHV）是一种与多种人类癌症相关的致癌性γ疱疹病毒。KSHV感染以及KSHV诱导的合成代谢细胞增殖和细胞转化依赖于细胞代谢途径的重编程，这些代谢途径为病毒和受感染细胞的生长提供了构建模块和能量。此外，KSHV会失调多种代谢传感器，包括mTOR、AMPK、CASTOR1和sirtuins，以在感染期间以及KSHV诱导的癌症中维持细胞能量稳态。在本综述中，我们总结了对KSHV劫持代谢途径和传感器的理解方面的最新进展，为KSHV感染和KSHV诱导的肿瘤发生的分子基础提供了见解。此外，我们强调了针对开发针对KSHV感染和KSHV诱导的癌症的潜在新疗法的关键代谢靶点和传感器。
