Department of Neurology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.
Muscle Nerve. 2018 Sep;58(3):407-412. doi: 10.1002/mus.26175.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients possess multiple risk factors for osteoporosis, but few studies have evaluated bone mineral density (BMD) in CIDP patients.
We retrospectively compared the BMD of CIDP patients with that of normal controls, and evaluated the clinical factors associated with osteoporosis.
Total BMD was lower in CIDP patients than in normal controls (P = 0.017). In a comparison of 16 osteoporotic CIDP patients with 25 non-osteoporotic patients, the cumulative prednisolone dose was lower (P = 0.022) and the duration from disease onset to BMD measurement was shorter (P = 0.014) in osteoporotic patients than in non-osteoporotic patients. Function, as measured by modified Rankin scale score within 3 years of the BMD measurement, was worse in osteoporotic than in non-osteoporotic patients (P = 0.008).
BMD in CIDP patients was significantly lower than in normal controls. Functional status rather than cumulative steroid dose was associated with osteoporosis. Muscle Nerve 58: 407-412, 2018.
慢性炎症性脱髓鞘性多发性神经病（CIDP）患者存在多种骨质疏松风险因素，但很少有研究评估 CIDP 患者的骨密度（BMD）。
我们回顾性比较了 CIDP 患者和正常对照者的 BMD，并评估了与骨质疏松相关的临床因素。
与正常对照组相比，CIDP 患者的总 BMD 较低（P = 0.017）。在对 16 例骨质疏松 CIDP 患者和 25 例非骨质疏松 CIDP 患者的比较中，骨质疏松患者的累积泼尼松剂量较低（P = 0.022），且从疾病发病到 BMD 测量的时间较短（P = 0.014）。与非骨质疏松患者相比，在 BMD 测量后 3 年内，使用改良 Rankin 量表评分评估的功能更差（P = 0.008）。
CIDP 患者的 BMD 明显低于正常对照组。骨质疏松与累积类固醇剂量无关，而与功能状态有关。神经肌肉 58: 407-412, 2018。
