Benham J L, Yamamoto J M, Friedenreich C M, Rabi D M, Sigal R J
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Clin Obes. 2018 Aug;8(4):275-284. doi: 10.1111/cob.12258. Epub 2018 Jun 12.
Preliminary evidence suggests exercise in polycystic ovary syndrome (PCOS) may improve reproductive and cardiometabolic parameters. Our primary aim was to determine the impact of exercise training on reproductive health in women with PCOS. Our secondary aim was to determine the effect of exercise training on cardiometabolic indices. A systematic review of published literature was conducted using MEDLINE and EMBASE based on a pre-published protocol (PROSPERO CRD42017065324). The search was not limited by year. Randomized controlled trials, non-randomized controlled trials and uncontrolled trials that evaluated an exercise intervention in women with PCOS and reported reproductive outcomes were included. Reproductive outcomes were analysed semi-quantitatively and a meta-analysis was conducted for reported cardiometabolic outcomes. Of 517 screened abstracts, 14 studies involving 617 women with PCOS were included: seven randomized controlled trials, one non-randomized controlled trial and six uncontrolled trials. There were insufficient published data to describe the effect of exercise interventions on ovulation quantitatively, but semi-quantitative analysis suggested that exercise interventions may improve menstrual regularity, pregnancy and ovulation rates. Our meta-analysis found that exercise improved lipid profiles and decreased waist circumference, systolic blood pressure and fasting insulin. The impact of exercise interventions on reproductive function remains unclear. However, our meta-analysis suggests that exercise interventions may improve cardiometabolic profiles in women with PCOS.
初步证据表明，多囊卵巢综合征（PCOS）患者进行运动可能会改善生殖和心脏代谢参数。我们的主要目的是确定运动训练对PCOS女性生殖健康的影响。我们的次要目的是确定运动训练对心脏代谢指标的影响。根据预先发表的方案（PROSPERO CRD42017065324），使用MEDLINE和EMBASE对已发表的文献进行了系统综述。检索不受年份限制。纳入了评估PCOS女性运动干预并报告生殖结局的随机对照试验、非随机对照试验和非对照试验。对生殖结局进行了半定量分析，并对报告的心脏代谢结局进行了荟萃分析。在517篇筛选的摘要中，纳入了14项涉及617名PCOS女性的研究：7项随机对照试验、1项非随机对照试验和6项非对照试验。目前发表的数据不足以定量描述运动干预对排卵的影响，但半定量分析表明，运动干预可能会改善月经规律、妊娠和排卵率。我们的荟萃分析发现，运动改善了血脂水平，降低了腰围、收缩压和空腹胰岛素水平。运动干预对生殖功能的影响仍不清楚。然而，我们的荟萃分析表明，运动干预可能会改善PCOS女性的心脏代谢状况。
