姜黄素与染料木黄酮联合抑制罗达明的药物组合研究。
Drug combination studies of curcumin and genistein against rhodesain of .
机构信息
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Messina , Italy.
Division of Hematology, Department of General Surgery, Pathological Anatomy and Oncology, University of Messina , Messina , Italy.
出版信息
Nat Prod Res. 2019 Dec;33(24):3577-3581. doi: 10.1080/14786419.2018.1483927. Epub 2018 Jun 13.
Curcumin and genistein are two natural products obtained from L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of ; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
姜黄素和染料木黄酮是两种从 L. 和大豆中提取的天然产物，具有许多生物特性。近年来，它们还被证明具有有前途的抗锥虫活性。在本文中，我们研究了姜黄素和染料木黄酮对 rhodesain 的活性， rhodesain 是 的主要半胱氨酸蛋白酶；根据 Chou 和 Talalay 方法进行的药物联合研究使我们能够证明姜黄素-染料木黄酮联合具有很强的协同作用。事实上，通过我们的实验，我们观察到姜黄素-染料木黄酮联合使 rhodesain 活性降低 10%至 90%时的组合指数 < 1。
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