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ORAI 通道作为肺动脉高压的潜在治疗靶点。

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension.

机构信息

INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux , Bordeaux , France.

Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds , Leeds , United Kingdom.

出版信息

Physiology (Bethesda). 2018 Jul 1;33(4):261-268. doi: 10.1152/physiol.00016.2018.

DOI:10.1152/physiol.00016.2018
PMID:29897302
Abstract

Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca channels. We review the knowledge about ORAI channels in pulmonary artery and discuss the interest to target them in the treatment of pulmonary hypertension.

摘要

肺动脉高压是一种复杂且致命的疾病，目前缺乏有效的治疗手段。其病理生理学涉及肺动脉高反应性、内皮功能障碍、血管壁重塑、炎症和血栓形成，这些都可能依赖于 ORAI Ca 通道。我们回顾了肺动脉 ORAI 通道的相关知识，并讨论了靶向治疗肺动脉高压的潜在意义。

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