通过癌胚抗原的免疫组织化学鉴定对唾液腺病变中的细胞进行特征描述。

Characterization of cells in salivary gland lesions by immunohistochemical identification of carcinoembryonic antigens.

作者信息

Tsukitani K, Kobayashi K, Murase N, Sumitomo S, Mitani H, Mori M

出版信息

Oral Surg Oral Med Oral Pathol. 1985 Jun;59(6):595-9. doi: 10.1016/0030-4220(85)90188-4.

Abstract

Immunohistochemical demonstration of carcinoembryonic antigen (CEA) was reported in normal salivary glands and in pathologic lesions. Staining patterns of CEA and nonspecific cross-reacting antigen-absorbed CEA (NCAa-CEA) were compared. Normal salivary glands disclosed positive staining by CEA on border and luminal sides of acinar cells and occasionally in components secreted into ductal spaces with both antigens used. Chronic obstructive lesions displayed an intense CEA staining in ductlike structures and in material secreted into their lumina in the two antigens used. Pleomorphic adenoma exhibited varying intensities of CEA in neoplastic epithelial cells of ductal structures. In contrast, they showed a slight staining reaction to NCAa-CEA. Squamous-cell carcinomas showed a strong CEA reaction, whereas they showed no reaction or a trace reaction to NCAa-CEA. Positive staining to CEA in squamous neoplastic lesions was related to nonspecific reacting antigens.

摘要

据报道，在正常唾液腺和病理病变中可通过免疫组织化学方法显示癌胚抗原（CEA）。对CEA和非特异性交叉反应抗原吸附的CEA（NCAa-CEA）的染色模式进行了比较。正常唾液腺在腺泡细胞的边界和腔面显示CEA阳性染色，偶尔在使用两种抗原时分泌到导管腔内的成分中也呈阳性染色。慢性阻塞性病变在使用的两种抗原中，在导管样结构及其腔内分泌的物质中均显示强烈的CEA染色。多形性腺瘤在导管结构的肿瘤上皮细胞中显示出不同强度的CEA。相比之下，它们对NCAa-CEA显示轻微的染色反应。鳞状细胞癌显示出强烈的CEA反应，而它们对NCAa-CEA无反应或仅有微量反应。鳞状肿瘤病变中CEA的阳性染色与非特异性反应抗原有关。