Baidan L V, Tishkin S M, Shuba M F
Pflugers Arch. 1985 Apr;403(4):429-32. doi: 10.1007/BF00589257.
Nonadrenergic synaptic transmission in circular and longitudinal smooth muscles of caecum preexposed to K-free solution for 4-5 h has been studied by means of sucrose gap technique. In addition, the effects of noradrenaline (NA) and ATP on these muscles were investigated under these conditions. The action of the above substances was accompanied by depolarization and contraction. NA induced a decrease in the membrane resistance. Addition of 0.5 mM Ba2+ to K-free solution intensified the depolarization. 1 mM of Mn2+ blocked depolarization and contraction. Intramural stimulation produced noncholinergic e.j.p.s blocked by TTX. Addition of 0.5 mM Ba2+ increased their amplitude. A reversal potential of both NA-induced depolarization and e.j.p. was in the range of + 10 to + 20 mV. It is supposed that e.j.p.s and depolarization observed in response to ATP and NA action are due to an increase in calcium permeability of the membrane.
利用蔗糖间隙技术研究了预先暴露于无钾溶液4 - 5小时的盲肠环行和纵行平滑肌中的非肾上腺素能突触传递。此外，在此条件下研究了去甲肾上腺素（NA）和ATP对这些肌肉的影响。上述物质的作用伴随着去极化和收缩。NA引起膜电阻降低。向无钾溶液中添加0.5 mM Ba2+增强了去极化。1 mM的Mn2+阻断了去极化和收缩。壁内刺激产生非胆碱能兴奋性接头电位（e.j.p.s），可被TTX阻断。添加0.5 mM Ba2+增加了它们的幅度。NA诱导的去极化和e.j.p.的反转电位在+10至+20 mV范围内。据推测，响应ATP和NA作用而观察到的e.j.p.s和去极化是由于膜钙通透性增加所致。
