Guo Zong-ru
Yao Xue Xue Bao. 2016 Aug;51(8):1179-84.
More attention has been paid to the pioneering drug innovation since the new millennium, while the creation space of fast-followed drugs is shrinking due to the serious risks observed in the clinical phases following marketing. Innovative drug discovery aiming at the brand new target is dependent on the breakthrough in basic biology, followed by chemical biology, and medicinal chemistry. This roadmap requires harmonious environment and free exploration atmosphere, while mandatory planning unlikely accelerates drug discovery. This article concisely analyzes several critical aspects of current status of drug discovery.
自新千年以来，人们对开拓性药物创新给予了更多关注，而由于上市后临床阶段观察到的严重风险，快速跟进药物的创新空间正在缩小。针对全新靶点的创新药物发现依赖于基础生物学的突破，其次是化学生物学和药物化学。这一路径需要和谐的环境和自由探索的氛围，而强制性规划不太可能加速药物发现。本文简要分析了药物发现现状的几个关键方面。
