Global Chemistry, Merck & Co. Inc., Kenilworth, NJ 07033, USA.
Janssen Research & Development LLC, Spring House, PA 19477, USA.
Science. 2019 Jan 18;363(6424). doi: 10.1126/science.aat0805.
Innovations in synthetic chemistry have enabled the discovery of many breakthrough therapies that have improved human health over the past century. In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter. We identify some of the most important recent advances in synthetic chemistry as well as opportunities at the interface with partner disciplines that are poised to transform the practice of drug discovery and development.
合成化学的创新使得许多突破性疗法得以发现，这些疗法在过去一个世纪改善了人类健康。面对制药行业日益增加的挑战，需要继续进行化学创新，以推动下一波药物的发现。新的合成方法不仅可以获得以前无法获得的化学物质，还可以激发我们设计和构建化学物质的新概念。我们确定了合成化学领域最近的一些最重要的进展，以及与即将改变药物发现和开发实践的合作伙伴学科接口的机会。
