Suppr超能文献

合成化学在制药行业中的重要性。

The importance of synthetic chemistry in the pharmaceutical industry.

机构信息

Global Chemistry, Merck & Co. Inc., Kenilworth, NJ 07033, USA.

Janssen Research & Development LLC, Spring House, PA 19477, USA.

出版信息

Science. 2019 Jan 18;363(6424). doi: 10.1126/science.aat0805.

Abstract

Innovations in synthetic chemistry have enabled the discovery of many breakthrough therapies that have improved human health over the past century. In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter. We identify some of the most important recent advances in synthetic chemistry as well as opportunities at the interface with partner disciplines that are poised to transform the practice of drug discovery and development.

摘要

合成化学的创新使得许多突破性疗法得以发现,这些疗法在过去一个世纪改善了人类健康。面对制药行业日益增加的挑战,需要继续进行化学创新,以推动下一波药物的发现。新的合成方法不仅可以获得以前无法获得的化学物质,还可以激发我们设计和构建化学物质的新概念。我们确定了合成化学领域最近的一些最重要的进展,以及与即将改变药物发现和开发实践的合作伙伴学科接口的机会。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验