对患有牙侵蚀症儿童唾液中氧化应激的评估。
Assessment of oxidative stress in saliva of children with dental erosion.
作者信息
Shitsuka Caleb, Ibuki Flávia Kazue, Nogueira Fernando Neves, Mendes Fausto Medeiros, Bönecker Marcelo
机构信息
Faculdade de Odontologia, Universidade de São Paulo, São Paulo, SP, Brazil.
出版信息
Einstein (Sao Paulo). 2018 Jun 11;16(2):eAO4203. doi: 10.1590/S1679-45082018AO4203.
OBJECTIVE
To evaluate oxidative stress in saliva of children with dental erosion as compared to children with no erosion.
METHODS
One single examiner, trained and prepared to make diagnosis of dental erosion according to the Basic Erosive Wear Examination index, selected 40 children aged 4 to 6 years, who attended a pediatric dentistry prevention clinic. Two groups were formed - one comprising children with dental erosion (n=22), and another with no dental erosion (n=18). The quantity of dental biofilm was verified using the Simplified Index of Oral Hygiene, and unstimulated saliva was collected for biochemical analyses. The following were assessed in saliva: flow rate, buffering capacity, pH, and total protein concentration. Malondialdehyde levels were also verified to determine oxidative stress and total antioxidant status.
RESULTS
The quantity of biofilm was smaller in children with mean dental erosion±standard deviation (0.76±0.25), as compared to those with no dental erosion (1.18±0.28). There was no statistical difference in saliva parameters of oxidative stress in children with dental erosion.
CONCLUSION
The activity of oxidative stress in saliva did not influence dental erosion process when in its early stages.
目的
评估患有牙侵蚀的儿童与未患牙侵蚀的儿童唾液中的氧化应激情况。
方法
一名经过培训并准备根据基本侵蚀性磨损检查指数进行牙侵蚀诊断的单一检查者，从一家儿童牙科预防诊所挑选了40名4至6岁的儿童。将他们分为两组，一组为患有牙侵蚀的儿童（n = 22），另一组为未患牙侵蚀的儿童（n = 18）。使用简化口腔卫生指数来验证牙菌斑的数量，并收集未刺激的唾液进行生化分析。对唾液中的以下指标进行评估：流速、缓冲能力、pH值和总蛋白浓度。还验证了丙二醛水平以确定氧化应激和总抗氧化状态。
结果
与未患牙侵蚀的儿童（1.18±0.28）相比，患有牙侵蚀的儿童的平均牙侵蚀±标准差（0.76±0.25）时牙菌斑数量较少。患有牙侵蚀的儿童唾液氧化应激参数无统计学差异。
结论
唾液中的氧化应激活动在牙侵蚀早期阶段并未影响其进程。
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