Department of Paediadtric Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Mol Diagn Ther. 2024 Jan;28(1):15-26. doi: 10.1007/s40291-023-00684-9.
Saliva can be used for screening and diagnostic purposes. Although multiple saliva collection methods are available, their use in children can be limited due to lack of cooperation, developmental stage, and age. The aim of this scoping review was to comprehensively appraise the different methods of saliva collection among both children and adolescents by assessing the available scientific literature.
A literature search was performed using the databases PubMed, Embase, and Web of Science. Eligible studies on saliva collection methods among children and adolescents were included for this review.
The literature search identified 249 eligible articles, of which 205 had a cross-sectional study design. Four distinct saliva collection methods have surfaced: the drooling method, the absorption method, the spitting method, and the suction method. Among infants or children under the age of 6 years, the suction and absorption methods were most preferred. The drooling and spitting methods were only applicable among children above the age of 3 years. When children were not willing to cooperate, the absorption method was most feasible. In adolescents and older children, no specific method was found to be preferred over another method.
Overall, saliva collection is well tolerated by children and adolescents, with the absorption and suction methods being preferred with young and uncooperative children.
唾液可用于筛查和诊断目的。尽管有多种唾液采集方法，但由于缺乏合作、发育阶段和年龄的限制，其在儿童中的应用可能受到限制。本综述的目的是通过评估现有文献，全面评估儿童和青少年的不同唾液采集方法。
使用 PubMed、Embase 和 Web of Science 数据库进行文献检索。纳入本综述的研究为儿童和青少年唾液采集方法的研究。
文献检索共确定了 249 篇符合条件的文章，其中 205 篇为横断面研究设计。有 4 种不同的唾液采集方法：流涎法、吸收法、吐口水法和抽吸法。在婴儿或 6 岁以下的儿童中，最常使用抽吸和吸收法。流涎法和吐口水法仅适用于 3 岁以上的儿童。当儿童不愿意合作时，吸收法最可行。在青少年和较大的儿童中，没有发现一种方法比另一种方法更受欢迎。
总的来说，儿童和青少年都能很好地耐受唾液采集，吸收法和抽吸法更受年幼和不合作的儿童的青睐。
