Yaghobee Siamak, Rouzmeh Nina, Aslroosta Hoori, Mahmoodi Sanaz, Khorsand Afshin, Kharrazifard Mohamad Javad
Tehran University of Medical Sciences, School of Dentistry, Department of Periodontics, Tehran, Iran.
Independent researcher, Novin Formula Consulting Group, Tehran, Iran.
Braz Oral Res. 2018 Jun 11;32:e55. doi: 10.1590/1807-3107bor-2018.vol32.0055.
Free gingival grafting, the most predictable technique to increase the keratinized gingiva, leaves an open wound on the palate and the resulting discomfort during the healing phase is a significant concern. This study was intended to evaluate the effect of topical erythropoietin on healing of the donor site. Twelve patients lacking an attached gingiva at two sites in the mandible were included. In the test group, 1 mL of gel containing erythropoietin at a concentration of 4,000 IU mL-1 was applied to the donor site, whereas the control group was treated with 2 mL of the gel alone. On the second day after surgery, the same procedure was repeated. H2O2 was used to evaluate the amount of epithelialization. Clinical healing was compared using photographs and direct examination. The EPO group showed significantly better keratinization only on day 21. Comparison of clinical healing based on direct examination revealed significantly better healing in the test group on day 28. Furthermore, inflammation in the test group was lower than in the control group on the same day. Topical application of EPO improves palatal wound healing during the third and fourth weeks after free gingival graft procedures.
游离龈移植术是增加角化龈最可预测的技术，但会在上腭留下开放性伤口，愈合期产生的不适是一个重大问题。本研究旨在评估局部应用促红细胞生成素对供区愈合的影响。纳入了12名下颌骨两个部位缺乏附着龈的患者。试验组在供区应用1 mL浓度为4000 IU/mL的含促红细胞生成素凝胶，而对照组仅用2 mL该凝胶治疗。术后第二天重复相同操作。用H2O2评估上皮化程度。通过照片和直接检查比较临床愈合情况。促红细胞生成素（EPO）组仅在第21天显示出明显更好的角化。基于直接检查的临床愈合比较显示，试验组在第28天愈合明显更好。此外，同一天试验组的炎症低于对照组。游离龈移植术后第三和第四周，局部应用促红细胞生成素可改善腭部伤口愈合。
