Periodontics Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Independent Researcher, Novin Formula Consulting Group, Tehran, Iran.
BMC Oral Health. 2021 Nov 12;21(1):578. doi: 10.1186/s12903-021-01948-8.
Free gingival graft (FGG) is a highly predictable method to increase the width of keratinized gingiva. Various materials have been reported to accelerate the wound healing process. Considering the positive effect of EPO on dermal wound healing this study aimed to investigate the effects of EPO on the rate of healing and degree of inflammation in free gingival grafts.
Seventeen patients with bilateral lack of keratinized gingiva in mandible were selected for this clinical trial. The surgical intervention was performed after phase I periodontal therapy. Recipient site was prepared apical to the mucogingival line, and FGG was harvested from the palate. Before graft placement, the test side and control side were treated with 1 ml of EPO 4000 IU/ml and distilled water, respectively, for 2 min. On days 7, 14, 21, 28, 60, and 90 after surgery, the grafted sites were examined by blinded observers to compare the healing and inflammation of the areas.
All the 17 patients completed the surgeries and follow-up examinations. Direct examination revealed significantly better healing in EPO group only on the 28th day. Assessment of the photographs showed a significant value in favor of the test group at some other time points as well. The EPO group demonstrated less inflammation, which was statistically significant in many time points. The graft area was 80.88 ± 30.21 mm and 71.35 ± 15.62 mm in the EPO and control groups, respectively. The difference was not significant, though.
Topical application of erythropoietin can accelerate the healing of gingival grafts and reduce the inflammation during healing period. The final graft outcome, nevertheless, does not seem to be influenced by EPO. Trial registration This was a split-mouth randomized controlled clinical trial (IRCT201201278830N1). The first registration date: 2016-10-22.
游离龈移植术（FGG）是一种增加角化龈宽度的高度可预测方法。已经有报道称，各种材料可以加速伤口愈合过程。鉴于 EPO 对真皮伤口愈合的积极影响，本研究旨在探讨 EPO 对游离龈移植术愈合速度和炎症程度的影响。
本临床试验选择了 17 名下颌双侧角化龈缺失的患者。在牙周一期治疗后进行手术干预。受体部位准备在龈黏膜线的根尖上方，从 palate 中采集 FGG。在放置移植物之前，分别用 1ml EPO 4000IU/ml 和蒸馏水处理测试侧和对照侧 2 分钟。术后第 7、14、21、28、60 和 90 天，由盲法观察者检查移植部位，以比较愈合和炎症情况。
所有 17 名患者均完成了手术和随访检查。直接检查仅显示 EPO 组在第 28 天愈合情况明显更好。对照片的评估也显示在其他一些时间点也有利于实验组。EPO 组的炎症程度较低，在许多时间点具有统计学意义。EPO 组和对照组的移植区域分别为 80.88±30.21mm 和 71.35±15.62mm。然而，差异无统计学意义。
局部应用促红细胞生成素可以加速牙龈移植的愈合，减少愈合期间的炎症。然而，EPO 似乎不会影响最终的移植结果。
这是一项分侧随机对照临床试验（IRCT201201278830N1）。首次注册日期：2016 年 10 月 22 日。
