多发性硬化症患者的自杀意念、焦虑和抑郁
Suicidal ideation, anxiety, and depression in patients with multiple sclerosis.
作者信息
Tauil Carlos Bernardo, Grippe Talyta Cortez, Dias Ronaldo Maciel, Dias-Carneiro Rafael Paternò Castello, Carneiro Narel Moita, Aguilar Ana Carolina Rodrigues, Silva Flávia Martins da, Bezerra Felipe, Almeida Leonardo Kenzo de, Massarente Vitoria Lana, Giovannelli Elaine de Carvalho, Tilbery Charles Peter, Brandão Carlos Otávio, Santos Leonilda Maria B, Santos-Neto Leopoldo Dos
机构信息
Hospital de Base de Brasília, Departamento de Neurologia, Brasília DF, Brasil.
Universidade Católica de Brasília, Brasília DF, Brasil.
出版信息
Arq Neuropsiquiatr. 2018 May;76(5):296-301. doi: 10.1590/0004-282X20180036.
INTRODUCTION
Psychiatric disorders frequently occur in patients with multiple sclerosis (MS); however, limited reports are available on these comorbidities. We aimed to investigate the relationships among MS, anxiety, depression, and suicidal ideation.
METHODS
One hundred and thirty two patients with relapsing-remitting MS were evaluated using the Expanded Disability Status Scale, Beck Depression Inventory-II (BDI-II), Beck Scale for Suicide Ideation (BSI), and Hospital Anxiety and Depression Scale.
RESULTS
A hierarchical regression analysis was performed to evaluate the variables. The regression equation significantly predicted the BSI score (R2 = 0.306; adjusted R2 = 0.273; F (9, 125) = 9.18; p < 0.0005), and the BDI-II score was the only variable that contributed significantly to this model (p < 0.0005).
CONCLUSIONS
A high prevalence of depression and anxiety, and a higher rate of suicidal ideation were identified in MS patients compared to the general population. The presence of depressive symptoms appeared to have a direct influence on the risk of suicide.
引言
精神疾病在多发性硬化症（MS）患者中经常出现；然而，关于这些合并症的报告有限。我们旨在研究MS、焦虑、抑郁和自杀意念之间的关系。
方法
使用扩展残疾状态量表、贝克抑郁量表第二版（BDI-II）、贝克自杀意念量表（BSI）和医院焦虑抑郁量表对132例复发缓解型MS患者进行评估。
结果
进行了分层回归分析以评估变量。回归方程显著预测了BSI评分（R2 = 0.306；调整后R2 = 0.273；F(9, 125) = 9.18；p < 0.0005），并且BDI-II评分是唯一对该模型有显著贡献的变量（p < 0.0005）。
结论
与普通人群相比，MS患者中抑郁和焦虑的患病率较高，自杀意念的发生率也较高。抑郁症状的存在似乎对自杀风险有直接影响。
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