Rocha Natalia Pessoa, Ferreira João Paulo Sampaio, Scalzo Paula Luciana, Barbosa Izabela Guimarães, Souza Mariana Soares de, Christo Paulo Pereira, Reis Helton José, Teixeira Antonio Lucio
The University of Texas Health Science Center at Houston, McGovern Medical School, Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, Houston, TX, USA.
Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica (LIIM), Belo Horizonte MG, Brasil.
Arq Neuropsiquiatr. 2018 May;76(5):310-315. doi: 10.1590/0004-282X20180035.
There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (BDNF), pro-BDNF, neurotrophin 3, neurotrophin 4, nerve growth, glial cell line-derived neurotrophic factor and ciliary neurotrophic factor were measured by enzyme-linked immunosorbent assay. There was no significant difference between PD patients and controls regarding the plasma levels of the evaluated NFs. In addition, NF levels were not associated with disease duration, degree of motor or functional impairment, cognitive performance or severity of depressive symptoms. In conclusion, although NFs may play relevant roles in the pathophysiology of PD, the circulating levels of these molecules are not necessarily changed in patients with PD.
有大量证据表明神经营养因子（NF）功能障碍与帕金森病（PD）的病理生理学有关。本研究旨在评估PD患者血浆中NF的水平及其与临床症状的可能关联。为此，对40例PD患者和25名对照者进行了临床评估并采集外周血。采用酶联免疫吸附测定法检测血浆中脑源性神经营养因子（BDNF）、前体BDNF、神经营养因子3、神经营养因子4、神经生长因子、胶质细胞源性神经营养因子和睫状神经营养因子的水平。在评估的NF血浆水平方面，PD患者与对照者之间没有显著差异。此外，NF水平与疾病持续时间、运动或功能损害程度、认知表现或抑郁症状严重程度无关。总之，尽管NF可能在PD的病理生理学中发挥相关作用，但这些分子的循环水平在PD患者中不一定会发生变化。
