Huang Yixian, Yun Wenwei, Zhang Min, Luo Weifeng, Zhou Xianju
1 Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, China.
3 Laboratory of Neurological Diseases, Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou, China.
J Int Med Res. 2018 Apr;46(4):1477-1485. doi: 10.1177/0300060517748843. Epub 2018 Jan 19.
Objectives The serum concentration of brain-derived neurotrophic factor (BDNF) was compared among patients with Parkinson's disease (PD), patients with essential tremor (ET), and healthy participants, and its association with clinical features of PD and ET was assessed. Methods Demographic and clinical data were collected from 60 patients with PD at different clinical stages, 60 patients with ET, and 60 controls. All participants' serum BDNF concentrations were measured. Their motor abilities and activity were assessed by the Unified PD Rating Scale and the Hoehn and Yahr (H-Y) staging scale. Results Serum BDNF was significantly lower in patients with PD than in patients with ET and controls. BDNF decreased only in the early disease stages (H-Y stages I and II), but increased markedly in the advanced stages (H-Y stages III-V). There was no significant difference between patients with ET and controls. The BDNF concentration was negatively correlated with age at PD onset and positively associated with disease duration, severity of PD symptoms, and treatment with L-DOPA. Conclusions A low serum BDNF concentration may serve as a biomarker in the early stages of PD, whereas a high concentration with PD progression may be due to treatment with L-DOPA in the advanced stages.
目的 比较帕金森病（PD）患者、特发性震颤（ET）患者和健康参与者的血清脑源性神经营养因子（BDNF）浓度，并评估其与PD和ET临床特征的相关性。方法 收集60例不同临床分期的PD患者、60例ET患者和60例对照者的人口统计学和临床资料。检测所有参与者的血清BDNF浓度。通过统一PD评定量表和Hoehn及Yahr（H-Y）分期量表评估他们的运动能力和活动情况。结果 PD患者的血清BDNF显著低于ET患者和对照者。BDNF仅在疾病早期（H-Y分期I和II）降低，但在晚期（H-Y分期III-V）显著升高。ET患者和对照者之间无显著差异。BDNF浓度与PD发病年龄呈负相关，与病程、PD症状严重程度及左旋多巴治疗呈正相关。结论 血清BDNF浓度低可能是PD早期的生物标志物，而随着PD进展浓度升高可能是晚期左旋多巴治疗所致。
