Armstrong R A, Jones R L, Wilson N H
Prostaglandins. 1985 May;29(5):703-13. doi: 10.1016/0090-6980(85)90131-5.
The thromboxane receptor antagonist EP 092 inhibits the acute pulmonary vascular response to E. coli endotoxin in the anaesthetized, closed-chest sheep. The increase in the TXB2 level in arterial blood was not suppressed by EP 092. Intravenous infusion of the thromboxane mimetic 11,9-epoxymethano PGH2, but not PGF2 alpha, raises pulmonary artery pressure and lowers arterial pO2 similar to the endotoxin. Isolated strips of lobar pulmonary veins but not lobar arteries are contracted by low concentrations of 11,9-epoxymethano PGH2 - the effects are potently inhibited by EP 092.
血栓素受体拮抗剂EP 092可抑制麻醉的、开胸绵羊对大肠杆菌内毒素的急性肺血管反应。动脉血中TXB2水平的升高未被EP 092抑制。静脉输注血栓素类似物11,9-环氧甲撑PGH2（而非PGF2α）可使肺动脉压升高，并使动脉血氧分压降低，其作用类似于内毒素。低浓度的11,9-环氧甲撑PGH2可使离体肺叶静脉条收缩，但对肺叶动脉条无此作用——这些作用可被EP 092有效抑制。
