• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effect of verapamil on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and a synthetic PGH2 analogue.维拉帕米对前列腺素F2α和一种合成PGH2类似物的肺血管收缩作用的影响。
Br J Pharmacol. 1981 May;73(1):101-3. doi: 10.1111/j.1476-5381.1981.tb16777.x.
2
Effects of intracellular and extracellular calcium blockers on the pulmonary vascular responses to PGF2 alpha and U46619.细胞内和细胞外钙阻滞剂对肺血管对前列腺素F2α和U46619反应的影响。
Angiology. 1987 Jan;38(1 Pt 1):51-5. doi: 10.1177/000331978703800107.
3
Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619.TMB - 8对前列腺素F2α和血栓素类似物U 46619的肺血管收缩作用的影响。
Br J Pharmacol. 1982 Sep;77(1):55-8. doi: 10.1111/j.1476-5381.1982.tb09268.x.
4
Effects of arachidonic acid, PGF2 alpha, and a PGH2 analogue on airway diameters in dogs.
J Appl Physiol Respir Environ Exerc Physiol. 1982 Oct;53(4):1005-14. doi: 10.1152/jappl.1982.53.4.1005.
5
Role of calcium in U 46619 and PGF2 alpha pulmonary vasoconstriction in rat lungs.
Am J Physiol. 1989 Dec;257(6 Pt 2):H2001-5. doi: 10.1152/ajpheart.1989.257.6.H2001.
6
Endotoxin priming of thromboxane-related vasoconstrictor responses in perfused rabbit lungs.内毒素引发灌注兔肺中血栓素相关的血管收缩反应。
J Appl Physiol (1985). 1997 Jul;83(1):18-24. doi: 10.1152/jappl.1997.83.1.18.
7
A role for prostaglandins in decidualization of the rat uterus.前列腺素在大鼠子宫蜕膜化中的作用。
J Endocrinol. 1981 Apr;89(1):25-33. doi: 10.1677/joe.0.0890025.
8
Endothelium-dependent and independent responses to prostaglandin H2 and arachidonic acid in isolated dog cerebral arteries.离体犬脑动脉对前列腺素H2和花生四烯酸的内皮依赖性和非内皮依赖性反应。
J Pharmacol Exp Ther. 1988 Jan;244(1):297-302.
9
Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.环氧合酶抑制对肺血管舒张反应至呋塞米的影响。
J Pharmacol Exp Ther. 1988 Jul;246(1):102-6.
10
Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.内过氧化物在花生四烯酸诱导的大鼠离体灌注肾血管收缩中的作用。
Br J Pharmacol. 1989 Jan;96(1):111-6. doi: 10.1111/j.1476-5381.1989.tb11790.x.

引用本文的文献

1
Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619.TMB - 8对前列腺素F2α和血栓素类似物U 46619的肺血管收缩作用的影响。
Br J Pharmacol. 1982 Sep;77(1):55-8. doi: 10.1111/j.1476-5381.1982.tb09268.x.

本文引用的文献

1
Calcium pools utilized for contraction in smooth muscle.平滑肌收缩所利用的钙池。
Am J Physiol. 1967 Nov;213(5):1299-304. doi: 10.1152/ajplegacy.1967.213.5.1299.
2
Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles.哺乳动物平滑肌中的肌浆网与兴奋-收缩偶联
J Cell Biol. 1972 Mar;52(3):690-718. doi: 10.1083/jcb.52.3.690.
3
Relative contributions of Ca2+ influx and cellular Ca2+ release during drug induced activation of the rabbit aorta.药物诱导兔主动脉激活过程中Ca2+内流和细胞内Ca2+释放的相对贡献。
Pflugers Arch. 1974 Apr 4;348(1):13-22. doi: 10.1007/BF00587735.
4
Vascular responses to arachidonic acid in the perfused canine lung.灌注犬肺中对花生四烯酸的血管反应。
Circ Res. 1976 Mar;38(3):167-71. doi: 10.1161/01.res.38.3.167.
5
Cardiovascular responses to three prostaglandin endoperoxide analogs in the dog.犬对三种前列腺素内过氧化物类似物的心血管反应。
Proc Soc Exp Biol Med. 1976 Nov;153(2):209-12. doi: 10.3181/00379727-153-39512.
6
Antagonism of the pulmonary vasoconstrictor response to prostaglandin F2alpha by N-dimethylamino substitution of prostaglandin F2alpha.通过对前列腺素F2α进行N - 二甲基氨基取代来拮抗其对肺血管收缩反应的作用。
J Pharmacol Exp Ther. 1978 Jul;206(1):139-42.

维拉帕米对前列腺素F2α和一种合成PGH2类似物的肺血管收缩作用的影响。

Effect of verapamil on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and a synthetic PGH2 analogue.

作者信息

Angerio A D, Fitzpatrick T M, Kot P A, Ramwell P W, Rose J C

出版信息

Br J Pharmacol. 1981 May;73(1):101-3. doi: 10.1111/j.1476-5381.1981.tb16777.x.

DOI:10.1111/j.1476-5381.1981.tb16777.x
PMID:7284690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071856/
Abstract

1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was not affected by the presence of verapamil. 3 The pulmonary pressor effect of PGF2 alpha and U-46619 is dependent, at least in part, on Ca2+ influx into vascular smooth muscle cells. 4 The pulmonary pressor response to AA cannot be attributed to PGF2 alpha or to endoperoxide intermediates but to some other product dependent on intracellular calcium stores.

摘要
  1. 在犬离体肺叶中，维拉帕米给药后，对前列腺素F2α（PGF2α）和（（15S）-羟基-11α，9α-（环氧亚甲基）-前列腺-5Z，13E-二烯酸）（U-46619）的血管加压反应显著减弱。2. 对花生四烯酸（AA）的升压反应不受维拉帕米存在的影响。3. PGF2α和U-46619的肺血管加压作用至少部分取决于Ca2+流入血管平滑肌细胞。4. 对AA的肺血管加压反应不能归因于PGF2α或内过氧化物中间体，而是归因于依赖细胞内钙储备的其他一些产物。