维拉帕米对前列腺素F2α和一种合成PGH2类似物的肺血管收缩作用的影响。
Effect of verapamil on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and a synthetic PGH2 analogue.
作者信息
Angerio A D, Fitzpatrick T M, Kot P A, Ramwell P W, Rose J C
出版信息
Br J Pharmacol. 1981 May;73(1):101-3. doi: 10.1111/j.1476-5381.1981.tb16777.x.
Abstract
1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was not affected by the presence of verapamil. 3 The pulmonary pressor effect of PGF2 alpha and U-46619 is dependent, at least in part, on Ca2+ influx into vascular smooth muscle cells. 4 The pulmonary pressor response to AA cannot be attributed to PGF2 alpha or to endoperoxide intermediates but to some other product dependent on intracellular calcium stores.
摘要
- 在犬离体肺叶中，维拉帕米给药后，对前列腺素F2α（PGF2α）和（（15S）-羟基-11α，9α-（环氧亚甲基）-前列腺-5Z，13E-二烯酸）（U-46619）的血管加压反应显著减弱。2. 对花生四烯酸（AA）的升压反应不受维拉帕米存在的影响。3. PGF2α和U-46619的肺血管加压作用至少部分取决于Ca2+流入血管平滑肌细胞。4. 对AA的肺血管加压反应不能归因于PGF2α或内过氧化物中间体，而是归因于依赖细胞内钙储备的其他一些产物。
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引用本文的文献
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