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沙特阿拉伯钙尿石症正常钙尿和高钙尿患者的钙代谢模式

Pattern of calcium metabolism in normo- and hypercalciuric patients with calcium urolithiasis in Saudi Arabia.

作者信息

Hanash K A, Bissada N K, Woodhouse N J

出版信息

Urology. 1985 Jul;26(1):27-32. doi: 10.1016/0090-4295(85)90249-3.

DOI:10.1016/0090-4295(85)90249-3
PMID:2990080
Abstract

Urinary calcium excretion was measured in 100 consecutive normocalcemic patients with calcium urolithiasis and 12 Saudi Arabian controls while the patients and the controls were eating their usual diet of unknown calcium content. Only 16 patients were hypercalciuric using the definition of twenty-four-hour urinary calcium of more than 300 mg for males and more than 250 mg for females, and one of these patients was subsequently found to have hyperparathyroidism. The twenty-four-hour urine calcium was less than 200 mg in 60 per cent of male patients and in all the male controls. Since the dietary intake of calcium during the twenty-four-hour urinary collection was unknown, a 1,000-mg calcium loading test was performed in an attempt to differentiate various patterns of abnormal calcium excretion. Of the twenty-four-hour normocalciuric patients 10 (18%) had "absorptive hypercalciuria" and 16 patients (29%) demonstrated a "renal hypercalciuria" pattern. Thirty-nine patients (57%) and all 12 controls had normocalciuria before and after calcium loading.

摘要

对100例连续性血钙正常的钙结石患者和12名沙特阿拉伯对照者在按平常饮食(钙含量未知)进食时测量尿钙排泄量。按照男性24小时尿钙超过300mg、女性超过250mg的定义,只有16例患者为高钙尿症,其中1例患者随后被发现患有甲状旁腺功能亢进症。60%的男性患者和所有男性对照者的24小时尿钙低于200mg。由于24小时尿液收集期间的饮食钙摄入量未知,因此进行了1000mg钙负荷试验,以试图区分各种异常钙排泄模式。在24小时血钙正常的患者中,10例(18%)有“吸收性高钙尿症”,16例患者(29%)表现为“肾性高钙尿症”模式。39例患者(57%)和所有12名对照者在钙负荷前后血钙正常。

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