Sağ Mustafa Serdar, Sağ Sinem, Tekeoğlu İbrahim, Kamanli Ayhan, Nas Kemal, Harman Halil
Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.
Arch Rheumatol. 2017 Sep 13;33(1):39-44. doi: 10.5606/ArchRheumatol.2018.6394. eCollection 2018 Mar.
This study aims to investigate the association of pentraxin 3 (PTX3) with neutrophil/lymphocyte ratio (NLR) rather than the disease activity score 28 using C-reactive protein in rheumatoid arthritis (RA).
The study included 59 RA patients (11 males, 48 females; mean age 53.79±13.55 years; range 40 to 66 years) and 20 healthy controls (5 males, 15 females; mean age 50.41±6.11 years; range 43 to 56 years). Complete blood count tests were recorded and NLR and platelet/ lymphocyte ratio were calculated. PTX3 and interleukin-6 levels were examined in serum samples. Disease activity of RA patients was assessed by disease activity score 28.
Demographic characteristics were similar between the two groups, with no statistically significant difference in terms of sex, age, and body mass index (p>0.05). NLR, PTX3 and interleukin-6 levels were higher in patients with RA than the control group (p<0.05). While erythrocyte sedimentation rate had a positive correlation with mean platelet volume, we found no correlation between NLR and other parameters of disease activity, PTX3, and interleukin-6.
We found no correlation between PTX3 and disease activity score 28 or NLR, although PTX3 levels were higher in RA patients than the controls. As a result, we were unable to establish a relationship between PTX3 and disease activity, directly or indirectly. To our knowledge, our study was the first to investigate the relationship between PTX3 and NLR.
本研究旨在探讨类风湿关节炎（RA）中五聚体3（PTX3）与中性粒细胞/淋巴细胞比值（NLR）的关联，而非使用C反应蛋白的疾病活动评分28。
该研究纳入了59例RA患者（11例男性，48例女性；平均年龄53.79±13.55岁；范围40至66岁）和20名健康对照者（5例男性，15例女性；平均年龄50.41±6.11岁；范围43至56岁）。记录全血细胞计数测试结果，并计算NLR和血小板/淋巴细胞比值。检测血清样本中的PTX3和白细胞介素-6水平。通过疾病活动评分28评估RA患者的疾病活动度。
两组的人口统计学特征相似，在性别、年龄和体重指数方面无统计学显著差异（p>0.05）。RA患者的NLR、PTX3和白细胞介素-6水平高于对照组（p<0.05）。虽然红细胞沉降率与平均血小板体积呈正相关，但我们发现NLR与疾病活动度、PTX3和白细胞介素-6的其他参数之间无相关性。
尽管RA患者的PTX3水平高于对照组，但我们发现PTX3与疾病活动评分28或NLR之间无相关性。因此，我们无法直接或间接建立PTX3与疾病活动之间的关系。据我们所知，我们的研究是首次探讨PTX3与NLR之间的关系。
