Maden Muhammet, Pamuk Gülsüm Emel, Pamuk Ömer Nuri
Department of Hematology, Medical Faculty of Trakya University Edirne, Turkey.
Department of Rheumatology, Medical Faculty of Trakya University Edirne, Turkey.
Arch Rheumatol. 2017 Feb 1;32(1):39-45. doi: 10.5606/ArchRheumatol.2017.6033. eCollection 2017 Mar.
This study aims to evaluate the mean platelet volume (MPV) and neutrophil-lymphocyte ratio (NLR) in gouty arthritis (GA) and rheumatoid arthritis (RA) patients, as well as their relationship with atherosclerotic cardiovascular mortality (ACVM).
The study included 122 GA patients (96 males, 26 females; mean age 64.6±13.4 years; range 34 to 82 years), 82 RA patients (40 males, 42 females; mean age 62.1±12.1 years; range 29 to 83 years), and 61 healthy controls (34 males, 27 females; mean age 65.3±4.8 years; range 33 to 80 years). Clinical and ACVM data were obtained from medical charts. Erythrocyte sedimentation rate, C-reactive protein, MPV, and NLR were recorded at the time of diagnosis and one month after therapy.
Mean platelet volume in GA (8.49±1.5) and RA (7.98±0.99) groups were significantly lower than in healthy controls (9.8±15) (p<0.001). NLR in healthy controls (1.9±0.74) was significantly lower than in GA (3.6±2.3) and RA (3.7±2.5) groups (p<0.001). After treatment, MPV did not change significantly in GA and RA groups (p values >0.05); however, NLR decreased in both groups (p<0.001). Nine GA and 12 RA patients died from ACVM during follow-up. GA patients with ACVM were older and had more frequent hypertension, higher MPV, and higher intercritical CRP level. In multivariate analysis, MPV was an independent poor prognostic factor for ACVM in GA patients.
Gouty arthritis and RA patients had significantly lower MPV and significantly higher NLR than controls. MPV might be used as a potential biomarker for the development of ACVM in GA.
本研究旨在评估痛风性关节炎（GA）和类风湿关节炎（RA）患者的平均血小板体积（MPV）和中性粒细胞与淋巴细胞比值（NLR），以及它们与动脉粥样硬化性心血管疾病死亡率（ACVM）的关系。
该研究纳入了122例GA患者（男性96例，女性26例；平均年龄64.6±13.4岁；年龄范围34至82岁）、82例RA患者（男性40例，女性42例；平均年龄62.1±12.1岁；年龄范围29至83岁）和61例健康对照者（男性34例，女性27例；平均年龄65.3±4.8岁；年龄范围33至80岁）。临床和ACVM数据从病历中获取。在诊断时和治疗后1个月记录红细胞沉降率、C反应蛋白、MPV和NLR。
GA组（8.49±1.5）和RA组（7.98±0.99）的平均血小板体积显著低于健康对照组（9.8±1.5）（p<0.001）。健康对照组的NLR（1.9±0.74）显著低于GA组（3.6±2.3）和RA组（3.7±2.5）（p<0.001）。治疗后，GA组和RA组的MPV无显著变化（p值>0.05）；然而，两组的NLR均下降（p<0.001）。随访期间，9例GA患者和12例RA患者死于ACVM。发生ACVM的GA患者年龄更大，高血压更常见，MPV更高，发作间期CRP水平更高。在多变量分析中，MPV是GA患者发生ACVM的独立不良预后因素。
痛风性关节炎和RA患者的MPV显著低于对照组，NLR显著高于对照组。MPV可能作为GA患者发生ACVM的潜在生物标志物。
