特发性间质性肺炎作为抗中性粒细胞胞浆抗体相关性血管炎的可能病因：一例报告
Idiopathic Interstitial Pneumonia as a Possible Cause of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report.
作者信息
Oiwa Hiroshi, Ooi Katsuhiro, Oyama Tetsu, Sugyama Eiji
机构信息
Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
出版信息
Arch Rheumatol. 2018 Jan 15;33(1):89-92. doi: 10.5606/ArchRheumatol.2018.6532. eCollection 2018 Mar.
Abstract
There are conflicting data to date on the causal relationship between idiopathic interstitial pneumonia and antineutrophil cytoplasmic antibody (ANCA): (1) myeloperoxidase-ANCA may play a pathogenetic role in pulmonary fibrosis, or (2) pulmonary fibrosis may induce production of the antibody. In this article, we describe a case of an elderly female patient with microscopic polyangiitis that developed after positive conversion of myeloperoxidase-ANCA during the course of idiopathic interstitial pneumonia. Our experience as well as similar case reports may suggest that idiopathic interstitial pneumonia may induce production of ANCAs and even ANCA-associated vasculitis.
摘要
目前关于特发性间质性肺炎与抗中性粒细胞胞浆抗体（ANCA）之间的因果关系存在相互矛盾的数据：（1）髓过氧化物酶-ANCA可能在肺纤维化中起致病作用，或者（2）肺纤维化可能诱导抗体产生。在本文中，我们描述了一例老年女性患者，在特发性间质性肺炎病程中髓过氧化物酶-ANCA转为阳性后发生了显微镜下多血管炎。我们的经验以及类似的病例报告可能提示，特发性间质性肺炎可能诱导ANCA产生，甚至引发ANCA相关性血管炎。
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Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis.中性粒细胞弹性蛋白酶促进肺纤维化中的肌成纤维细胞分化。
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