Amdii R E, Al' Shukri A S
Department of Urology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
Urologiia. 2018 May(2):114-120.
This literature review focuses on the use of Serenoa repens extracts in the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Extracts of Serenoa repens produce marked anti-inflammatory, anti-androgenic and antiproliferative effects. Various extracts differ in their activity depending on the concentration of free fatty acids and the method of extract preparation. Extracts of Serenoa Repens from different manufacturers vary considerably in composition, effectiveness and supporting evidence. Evaluation of the effectiveness of Serenoa Repens extracts should be carried out for each extract separately, depending on the method of preparation and brand. The most studied and clinically effective is the hexane lipidosterol extract of Serenoa Repens Permixon. This assessment is supported by a report on Serenoa Repens, issued by the European Medicines Agency. In this report, only Serenoa repens hexanic extract Permixon is considered to be a well-established medical use product for the symptomatic treatment of BPH.
本综述着重于锯叶棕提取物在治疗良性前列腺增生（BPH）和下尿路症状（LUTS）中的应用。锯叶棕提取物具有显著的抗炎、抗雄激素和抗增殖作用。不同的提取物因其游离脂肪酸浓度和提取物制备方法的不同而活性各异。不同厂家生产的锯叶棕提取物在成分、有效性和支持证据方面差异很大。应根据制备方法和品牌，对每种锯叶棕提取物的有效性分别进行评估。研究最多且临床效果最佳的是锯叶棕Permixon的己烷脂质甾醇提取物。欧洲药品管理局发布的一份关于锯叶棕的报告支持了这一评估。在该报告中，只有锯叶棕己烷提取物Permixon被认为是用于BPH症状性治疗的成熟医用产品。
