Tongdee Pattama, Loyd Ryan A, Kanoksin Suksan, Kanjanawetang Jantakan, Winwan Kaset, Nimkuntod Porntip
J Med Assoc Thai. 2016 Oct;99 Suppl 7:S36-41.
Evidence shows that lipid ratios perform better than individual lipids in predicting cardiovascular risk. The lipid ratio serves as a quick and simple tool for identifying subclinical atherosclerosis. The population at risk especially perimenopausal and menopausal women should be monitoring to prevent cardiovascular disease in the future.
To examine the association between lipid ratios and subclinical atherosclerosis by carotid intima media thickness (CIMT) in perimenopausal/menopausal women.
A cross-sectional study was conducted with 130 participants aged 40 to 80 years between February 2015 and January 2016 in Suranaree University of Technology Hospital, Thailand. CIMTs were assessed using a highresolution B mode ultrasound system. Traditional anthropometry, body mass index (BMI), waist circumference (WC), and parameters including blood pressure, fasting plasma glucose, lipid profile [Total cholesterol (TC), Triglyceride (TG), Highdensity lipoprotein cholesterol (HDL-C) and Low-density lipoprotein cholesterol (LDL-C)], and CIMT were assessed in all subjects. All lipid ratios were calculated.
One hundred thirty perimenopausal/menopausal participants were included in this study. Of those participants, 41% were central obese phenotype and 22% had abnormal CIMT that can identify atherosclerosis. Age and systolic blood pressure in atherosclerosis group were higher than normal CIMT group; <0.01 and <0.01, respectively. Lipid ratio in normal CIMT was higher than atherosclerotic group but not statistically significance except TG/HDL-C (p = 0.03). All lipid ratios and single lipid parameters lacked prediction for the presence of early atherosclerosis.
All of lipid ratios, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C were not identified as early subclinical atherosclerosis among perimenopausal/menopausal women.
有证据表明，在预测心血管风险方面，脂质比率比单一脂质表现更好。脂质比率是识别亚临床动脉粥样硬化的一种快速简便的工具。高危人群，尤其是围绝经期和绝经后女性，应进行监测以预防未来的心血管疾病。
通过围绝经期/绝经后女性的颈动脉内膜中层厚度（CIMT）来研究脂质比率与亚临床动脉粥样硬化之间的关联。
2015年2月至2016年1月在泰国宋卡王子大学技术学院医院对130名年龄在40至80岁之间的参与者进行了一项横断面研究。使用高分辨率B型超声系统评估CIMT。对所有受试者评估传统人体测量学指标、体重指数（BMI）、腰围（WC）以及包括血压、空腹血糖、血脂谱[总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）]和CIMT等参数。计算所有脂质比率。
本研究纳入了130名围绝经期/绝经后参与者。在这些参与者中，41%为中心性肥胖表型，22%有可识别动脉粥样硬化的异常CIMT。动脉粥样硬化组的年龄和收缩压高于正常CIMT组；分别为<0.01和<0.01。正常CIMT组的脂质比率高于动脉粥样硬化组，但除TG/HDL-C外无统计学意义（p = 0.03）。所有脂质比率和单一脂质参数均缺乏对早期动脉粥样硬化存在情况的预测能力。
在围绝经期/绝经后女性中，所有脂质比率，即TC/HDL-C、TG/HDL-C和LDL-C/HDL-C均未被识别为早期亚临床动脉粥样硬化。
