Juárez-López María Lilia Adriana, Solano-Silva Marlen Nicolett, Fragoso-Ríos Rodolfo, Murrieta-Pruneda Francisco
Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza Posgrado en Estomatología del Niño y Adolescente. Ciudad de México, México
Rev Med Inst Mex Seguro Soc. 2018 Mar-Apr;56(2):132-135.
Pediatric patients with acute lymphoblastic leukemia (ALL) usually develop oral manifestations due to the disease itself, as well as side effects of chemotherapy that severely affect their health and quality of life. The aim of this paperis to determine the prevalence of oral diseases in pediatric all patients with and without chemotherapy and its relation to the different phases of chemotherapy.
A cross-sectional observational study was conducted in 103 pediatric patients with all between 3-15 years. They were classified into groups: without chemotherapy and with chemotherapy at phase of consolidation, enhancement, maintenance and monitoring. Clinical diagnosis was performed and gingival inflammation index (IMPA) and caries criteria (dmf and DMF) were applied.
The prevalence oral manifestations in the chemotherapy group were mucositis (98%), ulcers (90%), gingivitis (86%) and candidiasis (78%). The induction phase related with mucositis: RM = 7.6, 95%CI: 4.4-13, p = 0.0001; candidiasis: OR = 103, 95%CI: 13.0-818, p = 0.0001; gingivitis: OR = 16.2, 95%CI: 5.5-47, p = 0.0001; ulcers OR = 61.5, 95%CI: 8.7-432, p = 0.0001.
The frequency and severity of oral diseases was hight and associated with the induction phase of chemotherapy, altering the overall nutrition and health of children.
急性淋巴细胞白血病（ALL）患儿通常会因疾病本身以及化疗副作用而出现口腔表现，这严重影响他们的健康和生活质量。本文旨在确定接受和未接受化疗的ALL患儿口腔疾病的患病率及其与化疗不同阶段的关系。
对103名3至15岁的ALL患儿进行了横断面观察性研究。他们被分为几组：未接受化疗组以及处于巩固、强化、维持和监测阶段的化疗组。进行了临床诊断，并应用了牙龈炎症指数（IMPA）和龋齿标准（dmf和DMF）。
化疗组口腔表现的患病率为：口腔黏膜炎（98%）、溃疡（90%）、牙龈炎（86%）和念珠菌病（78%）。诱导期与口腔黏膜炎相关：相对危险度（RR）=7.6，95%置信区间（CI）：4.4 - 13，p = 0.0001；念珠菌病：比值比（OR）=103，95%CI：13.0 - 818，p = 0.0001；牙龈炎：OR = 16.2，95%CI：5.5 - 47，p = 0.0001；溃疡OR = 61.5，95%CI：8.7 - 432，p = 0.0001。
口腔疾病的发生率和严重程度很高，且与化疗诱导期相关，改变了儿童的整体营养和健康状况。
