Aiempanakit Kumpol, Chiratikarnwong Kanokphorn, Chuaprapaisilp Thavatchai, Jandee Sawangpong, Auepemkiate Sauvarat
J Med Assoc Thai. 2016 Jul;99(7):823-7.
To study the correlation between the plasma zinc levels of Thai participants with alopecia areata (AA) and compare to the levels of Thais who do not have AA.
A cross-sectional study of thirty Thais with AA (case group) and thirty gender and age-matched healthy subjects (control group). All participants underwent blood tests measuring zinc and confounding factors.
Participants in both groups were the same gender, 20 (66.7%) women and 10 (33.3%) men. The median age was 37 in the study group and 38 in the control. In the study group, the median disease duration was three months (interquartile range 1-6). Patients who had AA for more than three months had a lower mean plasma zinc level than those who had AA for less than three months without statistical significance (58.33±8.59, 62.43±13.19 μg/dL (mean ± standard deviation or SD), respectively, p-value = 0.40). The correlation between plasma zinc levels and disease duration of AA (p-value = 0.31) and the plasma zinc levels and the Severity of Alopecia Tool (SALT) score (p-value = 0.16) were not statistically significant. The mean plasma zinc level in the study group was lower than in the control group with statistical significance (61.20±12.00, 67.17±10.04 μg/dL (mean ± SD), respectively, p-value = 0.04).
The plasma zinc level in participants with AA is statistically significantly lower than in participants without AA. A more in depth study should be conducted to determine whether prescribing zinc supplement would be of benefit to AA patients.
研究泰国斑秃（AA）患者血浆锌水平之间的相关性，并与无斑秃的泰国人血浆锌水平进行比较。
对30名患有AA的泰国人（病例组）和30名性别和年龄匹配的健康受试者（对照组）进行横断面研究。所有参与者均接受了测量锌及混杂因素的血液检测。
两组参与者性别相同，20名（66.7%）女性和10名（33.3%）男性。研究组的中位年龄为37岁，对照组为38岁。在研究组中，疾病中位持续时间为3个月（四分位间距为1 - 6个月）。斑秃超过3个月的患者平均血浆锌水平低于斑秃少于3个月的患者，但无统计学意义（分别为58.33±8.59、62.43±13.19μg/dL（均值±标准差或SD），p值 = 0.40）。血浆锌水平与斑秃疾病持续时间之间的相关性（p值 = 0.31）以及血浆锌水平与脱发严重程度工具（SALT）评分之间的相关性（p值 = 0.16）均无统计学意义。研究组的平均血浆锌水平低于对照组，具有统计学意义（分别为61.20±12.00、67.17±10.04μg/dL（均值±SD），p值 = 0.04）。
AA患者的血浆锌水平在统计学上显著低于无AA的患者。应进行更深入的研究以确定补充锌剂是否对AA患者有益。
