Markham R J, Ramnaraine M L
Am J Vet Res. 1985 Apr;46(4):879-83.
Bovine fetal lung tissue culture cells were infected with bovine viral diarrhea virus. The cells released substances into the supernatant fluid that suppressed the proliferative response of bovine peripheral blood mononuclear cells which had been stimulated with concanavalin A. Activity could be found in low molecular weight fractions (less than or equal to 2,000 daltons). During the assay, these fractions were required to inhibit the response of leukocytes to concanavalin A. Addition of indomethacin to the infected tissue culture cells inhibited generation of immunosuppressive supernatants; addition of indomethacin to the suppressive supernatants did not block their activity. The possible involvement of prostaglandins in this immunosuppressive activity is discussed.
牛胎儿肺组织培养细胞被牛病毒性腹泻病毒感染。这些细胞向上清液中释放了抑制经伴刀豆球蛋白A刺激的牛外周血单核细胞增殖反应的物质。在低分子量组分（小于或等于2000道尔顿）中可发现活性。在测定过程中，这些组分被要求抑制白细胞对伴刀豆球蛋白A的反应。向受感染的组织培养细胞中添加吲哚美辛可抑制免疫抑制性上清液的产生；向抑制性上清液中添加吲哚美辛并不能阻断其活性。文中讨论了前列腺素可能参与这种免疫抑制活性。
