Hu Weikang, Ying Mei, Zhang Shengmin, Wang Jianglin
J Biomed Nanotechnol. 2018 Aug 1;14(8):1359-1374. doi: 10.1166/jbn.2018.2590.
Micro/nanoscale carrier is a crucial component of the drug delivery system that enables to be well designed for improving the pharmacological and therapeutic properties of drug administration. Herein we systemically review a special vector of natural poly(amino acid) (PAA) that has been extensively applied in the controlled delivery of drug, protein and gene due to its excellent biocompatibility, controlled degradability, and flexible physicochemical modification. Natural PAA is a group of poly(ionic) molecules that present various biological roles and putative technical functions. The intention of this review is to thoroughly summarize three classic types of PAA involving anionic, cationic and neutral PAA as well as their applications on drug delivery systems.
微/纳米级载体是药物递送系统的关键组成部分，能够进行精心设计以改善药物给药的药理学和治疗特性。在此，我们系统地综述了一种特殊的天然聚氨基酸（PAA）载体，由于其优异的生物相容性、可控降解性和灵活的物理化学修饰，它已被广泛应用于药物、蛋白质和基因的控释。天然PAA是一类具有多种生物学作用和假定技术功能的聚离子分子。本综述的目的是全面总结三种经典类型的PAA，包括阴离子型、阳离子型和中性PAA，以及它们在药物递送系统中的应用。
