富含植物甾醇酯的牛奶对高胆固醇血症患者血液胆固醇的影响：一项随机对照试验

[Effect of milk enriched with phytosterol ester on blood cholesterol of patients with hypercholesterolemia: a randomized controlled trial].

作者信息

Zhu Jing, Shi Yunjie, Wang Yan, Wang Lili, Zhao Zifu

机构信息

Beijing Research Institute for Nutrition Resources, Beijing 100069, China.

出版信息

Wei Sheng Yan Jiu. 2016 Sep;45(5):718-732.

PMID:29903120

Abstract

OBJECTIVE

To study the effect of milk enriched with phytosterol ester on blood cholesterol.

METHODS

Participants with hypercholesterolemia were recruited from community health center and randomly assigned to 3 groups: milk enriched with phytosterol ester group( PS group, n = 59), normal milk group( n = 58) and non-dairy group( n = 62). The intervention lasted for 2 months. At baseline, all subjects in the 3groups received health education on prevention and control of hypercholesterolemia. For PS and normal milk groups, subjects consumed 500 g milk per day, the intake ofphytosterol in PS group was 1. 58 g / d. For non-dairy group, subjects did not consume any dairy products during the trial. Subjects were assessed on their physical activity level and blood cholesterols were measured during monthly follow-up.

RESULTS

Finally 157 subjects completed the trial. By the end of the first month, the TC and LDL-C levels of PS group were significantly lower than that of normal milk group. After adjustment, there was no significant difference between baseline and 1-month TC levels in PS group. The levels of TG and HDL-C in PS group were significantly increased while the LDL-C level was significantly decreased after 1-month intervention. Compared with normal milk and nondairy groups, no differences were observed for these four indicators. After 2-month intervention, the TC and LDL-C levels of PS group were significantly lower than that of normal milk and non-dairy groups. The levels of TC and LDL-C in PS group were significantly reduced compared to baseline levels after adjustment. TG level was increased while HDL-C level was unchanged. Compared with normal milk and non-dairy groups, the levels of TC and LDL-C in PS group were significantly declined while no significant difference was observed for TG and HDL-C levels.

CONCLUSION

s Milk enriched with phytosterol ester has a notable effect on lowering TC and LDL-C levels in subjects with hypercholesterolemia.

摘要

目的

研究富含植物甾醇酯的牛奶对血液胆固醇的影响。

方法

从社区卫生中心招募高胆固醇血症参与者，并随机分为3组：富含植物甾醇酯的牛奶组（PS组，n = 59）、普通牛奶组（n = 58）和非乳制品组（n = 62）。干预持续2个月。基线时，3组所有受试者均接受高胆固醇血症防治的健康教育。对于PS组和普通牛奶组，受试者每天饮用500 g牛奶，PS组植物甾醇摄入量为1.58 g/d。对于非乳制品组，受试者在试验期间不食用任何乳制品。评估受试者的身体活动水平，并在每月随访时测量血液胆固醇。

结果

最终157名受试者完成试验。到第一个月末，PS组的总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平显著低于普通牛奶组。调整后，PS组基线和1个月时的TC水平无显著差异。干预1个月后，PS组的甘油三酯（TG）水平显著升高，高密度脂蛋白胆固醇（HDL-C）水平显著升高，而LDL-C水平显著降低。与普通牛奶组和非乳制品组相比，这四项指标无差异。干预2个月后，PS组的TC和LDL-C水平显著低于普通牛奶组和非乳制品组。调整后，PS组的TC和LDL-C水平与基线水平相比显著降低。TG水平升高，而HDL-C水平未改变。与普通牛奶组和非乳制品组相比，PS组的TC和LDL-C水平显著下降，而TG和HDL-C水平无显著差异。