[Rapid screening of three halogenated salicylanilines in cosmetics using ambient ionization coupled with ion mobility spectrometry].

OBJECTIVE

A rapid analytical method had been developed for the screening of three halogenated salicylanilines in cosmetics using ambition ionization coupled with ion mobility spectrometry.

METHODS

Without time-consuming pretreatment, cosmetic samples of lotion, lipstick and powder were added or smudged onto a Grade 3MM chromatography paper for paper spray ionization, cosmetic samples of cream and shampoo were simply loaded with a metal wire probe for extraction nano-electrospray.

RESULTS

The limits of detection( LODs) for the three halogenated salicylanilides were 50 μg/kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 15 ms. The suspected positive samples were subjected to further verification by high-performance liquid chromatography coupled with tandem mass spectrometry.

CONCLUSION

The method is simple, rapid, and with low cost and is suitable for rapid, on-site screening of cosmetics.