KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium.
KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium.
Cytokine. 2018 Sep;109:65-71. doi: 10.1016/j.cyto.2018.02.022.
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. Here we review the role of CXCL4 and CXCL4L1 in cancer, the use of both chemokines as cancer biomarkers and discuss some possible therapeutic opportunities.
趋化因子在生理和病理条件下调节白细胞的迁移。目前人们认为，这些趋化细胞因子在癌症的发生和发展中也很重要。CXCL4 和其非等位基因变体 CXCL4L1 是两种与血小板相关的趋化因子，由于其具有抗血管生成潜力和趋化抗肿瘤白细胞的活性，被认为具有抗肿瘤活性。在这里，我们回顾了 CXCL4 和 CXCL4L1 在癌症中的作用、这两种趋化因子作为癌症生物标志物的应用，并讨论了一些可能的治疗机会。
