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细菌中的转座机制。

Mechanisms of transposition in bacteria.

作者信息

Berg D E

出版信息

Basic Life Sci. 1985;30:33-44. doi: 10.1007/978-1-4613-2447-8_5.

DOI:10.1007/978-1-4613-2447-8_5
PMID:2990415
Abstract

The transposable elements of bacteria are diverse in size, functional arrangement, DNA sequence, and in their modes of transposition. We review here data suggesting that the kanamycin-resistance transposon Tn5 moves without replicating (conservative transposition), but the ampicillin-resistance transposon Tn3 is duplicated when it transposes, and that both the chloramphenicol-resistance transposon Tn9 and bacteriophage Mu are replicated in some events but not in others. A model is presented in which conservative and replicative transposition are alternative branches of a single pathway.

摘要

细菌的转座元件在大小、功能排列、DNA序列及其转座方式上各不相同。我们在此回顾一些数据,这些数据表明卡那霉素抗性转座子Tn5在转座时不进行复制(保守转座),但氨苄青霉素抗性转座子Tn3在转座时会被复制,并且氯霉素抗性转座子Tn9和噬菌体Mu在某些情况下会复制,但在其他情况下则不会。本文提出了一个模型,其中保守转座和复制性转座是单一途径的两个分支。

相似文献

1
Mechanisms of transposition in bacteria.细菌中的转座机制。
Basic Life Sci. 1985;30:33-44. doi: 10.1007/978-1-4613-2447-8_5.
2
Evidence for replicative transposition of Tn5 and Tn9.Tn5和Tn9复制性转座的证据。
J Mol Biol. 1986 Sep 5;191(1):75-84. doi: 10.1016/0022-2836(86)90423-7.
3
Tn5 transposes independently of cointegrate resolution. Evidence for an alternative model for transposition.Tn5转座独立于共整合体的拆分。转座替代模型的证据。
J Mol Biol. 1985 Mar 5;182(1):69-78. doi: 10.1016/0022-2836(85)90028-2.
4
[Bacterial transposons and the mechanisms of their transposition].
Genetika. 1986 Nov;22(11):2572-82.
5
A comparison of intramolecular rearrangements promoted by transposons Tn5 and Tn10.转座子Tn5和Tn10促进的分子内重排的比较。
Proc Biol Sci. 1991 Apr 22;244(1309):1-9. doi: 10.1098/rspb.1991.0043.
6
Alternative mechanisms for tn5 transposition.Tn5转座的替代机制。
PLoS Genet. 2009 Aug;5(8):e1000619. doi: 10.1371/journal.pgen.1000619. Epub 2009 Aug 28.
7
[Analysis of insertions of the determinant of drug resistance to kanamycin and chloramphenicol into bacteriophage lambda att80].[对卡那霉素和氯霉素耐药性决定因子插入噬菌体λ att80的分析]
Zh Mikrobiol Epidemiol Immunobiol. 1982 Jul(7):79-82.
8
Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.Tn1331,一种编码肺炎克雷伯菌对阿米卡星和氨苄西林耐药性的新型多耐药转座子。
Antimicrob Agents Chemother. 1987 Dec;31(12):1955-60. doi: 10.1128/AAC.31.12.1955.
9
[Different effect of mutations in Escherichia coli K12 dna-genes on the transposition of Tn5- and Tn10-elements].[大肠杆菌K12 dna基因中的突变对Tn5和Tn10元件转座的不同影响]
Mol Gen Mikrobiol Virusol. 1985 Jan(1):9-12.
10
[Formation of covalently-bound circular structures of transposon TnV (Tn5-Rep pSC101) during transposition].[转座过程中转座子TnV(Tn5 - Rep pSC101)共价结合环状结构的形成]
Dokl Akad Nauk SSSR. 1989;309(3):724-8.

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