肾衰竭中的氟卡尼毒性
Flecainide toxicity in renal failure.
作者信息
Subedi Rogin, Dean Ryan K, Chaudhary Arbind, Szombathy Tamas
机构信息
Department of Medicine, State University of New York Upstate Medical University, Syracuse, New York.
Department of Cardiology, State University of New York Upstate Medical University, Syracuse, New York.
出版信息
Proc (Bayl Univ Med Cent). 2018 May 9;31(3):328-330. doi: 10.1080/08998280.2018.1463042. eCollection 2018 Jul.
Abstract
Flecainide, a class Ic antiarrhythmic, is used for the prevention of paroxysmal supraventricular tachycardia, paroxysmal atrial fibrillation/flutter, and sustained ventricular tachycardia. Flecainide is primarily metabolized by the liver and to a lesser extent (30%) is excreted unchanged in the kidney. We present a case of flecainide toxicity in the setting of renal impairment that was successfully treated with intravenous sodium bicarbonate.
摘要
氟卡尼是一种Ic类抗心律失常药物，用于预防阵发性室上性心动过速、阵发性心房颤动/扑动和持续性室性心动过速。氟卡尼主要在肝脏代谢，少量（30%）以原形经肾脏排泄。我们报告一例在肾功能损害情况下发生氟卡尼中毒的病例，该病例经静脉注射碳酸氢钠成功治疗。
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