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心房颤动与慢性肾脏病:病因与管理

Atrial Fibrillation and Chronic Kidney Disease: Aetiology and Management.

作者信息

Sidhu Bharat, Mavilakandy Akash, Hull Katherine L, Koev Ivelin, Vali Zakariyya, Burton James O, Ng G André

机构信息

Department of Cardiovascular Sciences, University of Leicester, LE1 7RH Leicester, UK.

Department of Cardiology, University Hospitals of Leicester NHS Trust, LE1 5WW Leicester, UK.

出版信息

Rev Cardiovasc Med. 2024 Apr 9;25(4):143. doi: 10.31083/j.rcm2504143. eCollection 2024 Apr.

DOI:10.31083/j.rcm2504143
PMID:39076563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11264032/
Abstract

Chronic kidney disease (CKD) and atrial fibrillation (AF) are associated with significant cardiovascular morbidity and mortality. Recent studies have highlighted an increased prevalence and incidence of AF in patients with CKD. This article aims to provide a comprehensive review of current management strategies and considerations of treating atrial fibrillation with concomitant CKD. Potential electrophysiological mechanisms between AF and CKD are explored. Current evidence and literature focusing on pharmacological rate and rhythm control along with procedural intervention is reviewed and presented. The management of AF and CKD together is complex, but particularly pertinent when considering the close cyclical relationship in the progression of both diseases.

摘要

慢性肾脏病(CKD)和心房颤动(AF)与显著的心血管发病率和死亡率相关。近期研究强调了CKD患者中AF患病率和发病率的增加。本文旨在全面综述当前治疗合并CKD的心房颤动的管理策略及注意事项。探讨了AF与CKD之间潜在的电生理机制。对聚焦于药物心率和节律控制以及手术干预的现有证据和文献进行了综述和阐述。AF和CKD的共同管理很复杂,但在考虑两种疾病进展中的紧密循环关系时尤为相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c27/11264032/01e233466a74/2153-8174-25-4-143-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c27/11264032/01e233466a74/2153-8174-25-4-143-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c27/11264032/01e233466a74/2153-8174-25-4-143-g1.jpg

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Association of digoxin with mortality in patients with advanced chronic kidney disease: A population-based cohort study.地高辛与晚期慢性肾脏病患者死亡率的相关性:基于人群的队列研究。
PLoS One. 2021 Jan 15;16(1):e0245620. doi: 10.1371/journal.pone.0245620. eCollection 2021.
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ACE Inhibitor Benefit to Kidney and Cardiovascular Outcomes for Patients with Non-Dialysis Chronic Kidney Disease Stages 3-5: A Network Meta-Analysis of Randomised Clinical Trials.血管紧张素转换酶抑制剂对非透析慢性肾脏病 3-5 期患者的肾脏和心血管结局的益处:随机临床试验的网络荟萃分析。
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2011年至2020年美国因慢性肾病相关心房颤动导致的成年人死亡率趋势。
World J Cardiol. 2025 May 26;17(5):105919. doi: 10.4330/wjc.v17.i5.105919.
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Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure.心力衰竭发病机制与进展中的肾心交互作用
Circ Res. 2025 May 23;136(11):1306-1334. doi: 10.1161/CIRCRESAHA.124.325488. Epub 2025 May 22.
Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study.
慢性肾脏病伴新发心房颤动患者透析治疗的长期结局:基于人群的队列研究。
PLoS One. 2019 Sep 19;14(9):e0222656. doi: 10.1371/journal.pone.0222656. eCollection 2019.
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