Benn Caroline L, Dua Pinky, Gurrell Rachel, Loudon Peter, Pike Andrew, Storer R Ian, Vangjeli Ciara
Pfizer Ltd., Cambridge, United Kingdom.
DMPK, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
Front Med (Lausanne). 2018 May 31;5:160. doi: 10.3389/fmed.2018.00160. eCollection 2018.
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes. Finally, we discuss current therapies and emerging drug discovery efforts aimed at delivering an optimized clinical treatment strategy.
痛风是炎症性关节炎最常见的形式，是一种多因素疾病，其典型特征是高尿酸血症以及主要（但不限于）在关节和尿路中的尿酸钠晶体沉积。在过去二十年中，发达国家痛风和高尿酸血症的患病率有所上升，该领域的研究也日益活跃。我们综述了当前的知识领域，重点关注高尿酸血症研究的活跃领域，包括基础生理学、遗传学和流行病学，尤其关注那些表明高尿酸血症与常见合并症（包括心血管疾病、肾功能不全、代谢综合征和糖尿病）之间存在关联的研究。最后，我们讨论了当前的治疗方法以及旨在提供优化临床治疗策略的新兴药物研发工作。
