Shute J K, Smith M E
Biochem Pharmacol. 1985 Jul 15;34(14):2471-5. doi: 10.1016/0006-2952(85)90528-3.
The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and the quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.
测定了骨骼肌胞质溶胶中钙依赖性磷脂酰肌醇磷酸二酯酶的活性。该酶受到Zn2+、Cu2+和Pb2+离子的抑制，但Mg2+和Mn2+没有影响。抗疟药物氯喹、奎宁以及氨基糖苷类抗生素庆大霉素和新霉素，所有这些药物都像Zn2+一样已被证明会阻断神经肌肉传递，它们也抑制该酶。
