Anitua Eduardo, Pino Ander, Jaén Pedro, Navarro Mª Rogelia
BTI Biotechnology Institute, Vitoria, Spain.
Eduardo Anitua Foundation, Vitoria, Spain.
J Cosmet Dermatol. 2019 Apr;18(2):483-486. doi: 10.1111/jocd.12683. Epub 2018 Jun 14.
Platelet-rich plasma (PRP) and autologous protein-based treatments have recently emerged as a potential therapeutic approach for hair loss-related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs. Interestingly, further studies have revealed that combining PRP with other hair loss-related products may enhance the final performance of the treatment. These synergistic approaches include Food and Drug Administration (FDA) approved drugs such as finasteride or minoxidil, bioactive macromolecules and cell-based therapies. Here, recent research involving alone or combined therapy with platelet-rich plasma for the management of hair loss-related disorders are outlined and future prospects are discussed.
富含血小板血浆（PRP）和基于自体蛋白的治疗方法最近已成为治疗包括雄激素性脱发和斑秃在内的脱发相关疾病的一种潜在治疗手段。在多项随机临床试验中，反复皮内注射PRP的安全性和有效性已被证明可促进头发生长。血小板激活后释放的生物活性蛋白和细胞因子已显示出可诱导毛囊形成并激活休眠毛囊的生长期。有趣的是，进一步的研究表明，将PRP与其他脱发相关产品联合使用可能会提高治疗的最终效果。这些协同方法包括美国食品药品监督管理局（FDA）批准的药物，如非那雄胺或米诺地尔、生物活性大分子和基于细胞的疗法。在此，概述了最近关于单独使用或联合富含血小板血浆治疗脱发相关疾病的研究，并讨论了未来前景。
