Department of Surgical Science, Plastic and Reconstructive Surgery, "Tor Vergata" University, 00133 Rome, Italy.
Institute of Dermatology, F. Policlinico Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Int J Mol Sci. 2020 Apr 13;21(8):2702. doi: 10.3390/ijms21082702.
The number of articles evaluating platelet-rich plasma (PRP) efficacy in androgenic alopecia (AGA) have exponentially increased during the last decade. A systematic review on this field was performed by assessing in the selected studies the local injections of PRP compared to any control for AGA. The protocol was developed in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidelines. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases was performed to identify studies on hair loss treatment with platelet-rich plasma. Of the 163 articles initially identified, 123 articles focusing on AGA were selected and, consequently, only 12 clinical trials were analyzed. The studies included had to match predetermined criteria according to the PICOS (patients, intervention, comparator, outcomes, and study design) approach. In total, 84% of the studies reported a positive effect of PRP for AGA treatment. Among them, 50% of the studies demonstrated a statistically significant improvement using objective measures and 34% of the studies showed hair density and hair thickness improvement, although no values or statistical analysis was described. In total, 17% of the studies reported greater improvement in lower-grade AGA, while 8% noted increased improvement in higher-grade AGA. Only 17% of the studies reported that PRP was not effective in treating AGA. The information analyzed highlights the positive effects of PRP on AGA, without major side effects and thus it be may considered as a safe and effective alternative procedure to treat hair loss compared with Minoxidil and Finasteride.
在过去十年中，评估富血小板血浆 (PRP) 在雄激素性脱发 (AGA) 中的疗效的文章数量呈指数级增长。通过评估所选研究中 PRP 与任何 AGA 对照的局部注射，对该领域进行了系统评价。该方案是根据系统评价和荟萃分析首选报告项目-方案 (PRISMA-P) 指南制定的。对 PubMed、MEDLINE、Embase、PreMEDLINE、Ebase、CINAHL、PsycINFO、Clinicaltrials.gov、Scopus 数据库和 Cochrane 数据库进行了多步骤搜索，以确定关于富含血小板的血浆治疗脱发的研究。在最初确定的 163 篇文章中，选择了 123 篇关于 AGA 的文章，因此仅分析了 12 项临床试验。这些研究必须根据 PICOS（患者、干预、对照、结局和研究设计）方法符合预定标准。总共，84%的研究报告 PRP 对 AGA 治疗有积极影响。其中，50%的研究使用客观测量显示出统计学上的显著改善，34%的研究显示出毛发密度和毛发厚度的改善，尽管没有描述 值或统计分析。总共，17%的研究报告在较低等级的 AGA 中改善更大，而 8%的研究报告在较高等级的 AGA 中改善更大。只有 17%的研究报告 PRP 对 AGA 治疗无效。分析的信息强调了 PRP 对 AGA 的积极影响，没有重大副作用，因此与米诺地尔和非那雄胺相比，它可能被认为是一种安全有效的替代治疗脱发的方法。
