Flemming Juliana, Wiesen Lisa, Herschhorn Alon
Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota , Minneapolis, Minnesota.
AIDS Res Hum Retroviruses. 2018 Sep;34(9):794-803. doi: 10.1089/AID.2018.0102. Epub 2018 Jul 17.
HIV type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an intermediate step. Recent studies have revealed new insights on the dynamics, regulation, and molecular mechanisms of Env transitions along the entry pathway. In this study, we provide an overview of the current knowledge on Env conformational dynamics and the relationship between Env conformational states and neutralization selectivity of the broadly neutralizing antibodies that develop in 10%-20% of infected individuals and may provide guidance for the development of an effective HIV-1 vaccine.
1型人类免疫缺陷病毒（HIV-1）包膜糖蛋白（Env）介导病毒进入细胞，并且是中和抗体的作用靶点。亚稳态HIV-1 Env三聚体与CD4受体的结合会触发结构重排，该重排通过一个中间步骤介导Env从封闭构象到更开放状态的构象转变。最近的研究揭示了关于Env在进入途径中的动力学、调节和分子机制的新见解。在本研究中，我们概述了目前关于Env构象动力学的知识，以及Env构象状态与在10%-20%的受感染个体中产生的广泛中和抗体的中和选择性之间的关系，这些知识可能为开发有效的HIV-1疫苗提供指导。
