[MODERN APPROACHES TO THE TREATMENT OF MULTIPLE SCLEROSIS (REVIEW AND CLINICAL CASE)].

Multiple sclerosis is a chronic dysimmune neurodegenerative disease of the central nervous system, that affects people of working age and inevitably leads to disability. Treatment of the disease is one of the urgent problems of modern clinical neurology, which is explained by the variety of clinical variants of the flow, the lack of an effective method of treatment. This article is devoted to a review of modern approaches to the issues of etiology, pathogenesis and treatment of multiple sclerosis. Also, the classification of multiple sclerosis depending on the course of the disease, data on modern approaches to the treatment of multiple sclerosis, the criteria for the appointment of differentiated therapy depending on the course of the disease with the use of Disease-Modifying Drugs (DMDs) are given. The main strategies for the use of DMDs are described: escalation and de-escalation. The authors of the article presented a clinical case of observation and treatment of a patient with a remitting-relapsing type of multiple sclerosis with a rapid transformation to the secondary-progressive course. The analysis of the dynamics of clinical manifestations with the reflection of the degree of progression on the EDSS scale, analysis of the the radiological study data, as well as the analysis of the prescription of the drugs of the first-line and the second-line treatment to this patient during the observation period from 2010 to 2017 are given.