Laboratory Division, Ayder Comprehensive Specialized Hospital, Mekelle University, Mekelle, Ethiopia.
Medical Microbiology and Immunology Department, Mekelle University, Mekelle, Ethiopia.
J Med Virol. 2018 Nov;90(11):1724-1729. doi: 10.1002/jmv.25248. Epub 2018 Jul 13.
Blood transfusion services are a vital and integral part of modern healthcare services. However, the risk of transfusion transmittable infections (TTI) has been a major handicap. Therefore, this study was aimed at determining the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) among blood donors. A retrospective study was conducted to collect data about the blood donors who consecutively donated blood from October 2011 to 2014. A three-year retrospective study was conducted in Mekelle Blood Bank. A data abstraction format was used to collect the sociodemographic and clinical data, and the prevalence of HBV, HCV, and HIV was determined. Data were analyzed using STATA version 10 analytical software. P value less than 0.05 was considered significant in all the analyses. A total of 10 728 blood donors, median (interquartile range) of age 30 (23-45) years and 3750 (34.9%) males were enrolled in this study. Of the participants 407(3.79%), 143(1.33%), and 111(1.03%) blood donors were positive for HBV, HCV, and HIV, respectively. HBV-HIV coinfections were found 10 (1.93%) blood donors, followed by HBV-HCV and HIV-HCV. A significant association between sex and marital status with HBV and HIV infection was found. However, significant association of HCV was observed among sex ( X = 33.18, P < 0.001) and occupational ( X = 84.33, P < 0.001). A significant percentage of HBV, HCV, and HIV among blood donors was observed. To select a donor and collect safe blood risk factors exposing blood donor should be studied, and community-based prevalence studies on TTI are also required.
输血服务是现代医疗保健服务中至关重要的组成部分。然而，输血传播感染（TTI）的风险一直是一个主要障碍。因此，本研究旨在确定献血者中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）的流行率。
本研究采用回顾性研究方法，收集了 2011 年 10 月至 2014 年连续献血的献血者的数据。在梅克尔血库进行了一项为期三年的回顾性研究。使用数据提取格式收集社会人口学和临床数据，并确定 HBV、HCV 和 HIV 的流行率。使用 STATA 版本 10 分析软件进行数据分析。所有分析中，P 值小于 0.05 被认为具有统计学意义。
共有 10728 名献血者，年龄中位数（四分位间距）为 30（23-45）岁，男性 3750 人（34.9%）。参与者中，HBV、HCV 和 HIV 阳性者分别为 407 人（3.79%）、143 人（1.33%）和 111 人（1.03%）。10 名（1.93%）献血者为 HBV-HIV 合并感染，其次是 HBV-HCV 和 HIV-HCV。
性别和婚姻状况与 HBV 和 HIV 感染呈显著相关，而 HCV 与性别（X²=33.18，P<0.001）和职业（X²=84.33，P<0.001）显著相关。
观察到献血者中 HBV、HCV 和 HIV 的比例较高。为了选择供者和采集安全血液，应研究暴露供者的风险因素，还需要进行基于社区的 TTI 患病率研究。
