一种从蜂斗菜根茎中提取的新型抗缺氧倍半萜。

A new anti-hypoxia sesquiterpene from the rhizome of Petasites japonicas.

作者信息

Xie Yao-yu, Li Yu-xian, Sun Yi-ming, Wang Yan, Guo Mei-li

出版信息

Yao Xue Xue Bao. 2016 Aug;51(8):1285-9.

Abstract

A new sesquiterpene, bakkenolide-Ⅵa (1), was isolated from the rhizome of Petasites japonicas (Sieb. et Zucc.) Maxim. The structure was characterized on the basis of various NMR ((1)H, (13)C, (1)H-(1)H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. Bakkenolide-Ⅵa showed potent cerebral hypoxia- ischemia protective activity in mice subjected to decapitation through prolonging the survival time and gasping time. It also exhibited a protective activity against hypoxia injury in PC12 cells in anaerobic culture by inhibition of lactate dehydrogenase (LDH) release.

摘要

从蜂斗菜（Petasites japonicas (Sieb. et Zucc.) Maxim.）的根茎中分离出一种新的倍半萜——蜂斗内酯-Ⅵa（1）。通过各种核磁共振（（1）H、（13）C、（1）H-（1）H 化学位移相关谱、异核多量子相干谱、异核多键相关谱和核Overhauser效应谱）和质谱数据对其结构进行了表征。蜂斗内酯-Ⅵa在通过断头处理的小鼠中表现出强大的脑缺氧缺血保护活性，可延长存活时间和喘息时间。它还通过抑制乳酸脱氢酶（LDH）释放，对厌氧培养的PC12细胞中的缺氧损伤表现出保护活性。