College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
Food Chem. 2013 Dec 1;141(3):2075-82. doi: 10.1016/j.foodchem.2013.04.116. Epub 2013 May 9.
Neuroprotective reagents to protect the nerve cells against oxidative stress and other damages are potentially effective for the medical treatment of Parkinson's disease. Petasites japonicus, a wild vegetable, belongs to the family Compositae and its extract has shown the neuroprotective effects. A further phytochemical investigation of P. japonicus for neuroprotective substances led to the isolation of eight new (1-8) and two known (9 and 10) sesquiterpenes. Their structures were elucidated on the basis of extensive 1D and 2D NMR (HMQC, HMBC, (1)H-(1)H COSY, and NOESY) spectroscopic data analyses, and the structure of 1 was confirmed by X-ray crystallography. The neuroprotective activities of these sesquiterpenes were evaluated against cobalt chloride (CoCl2)-induced neuronal cell death in human dopaminergic SH-SY5Y cells. Five compounds showed a neuroprotective activity.
神经保护试剂可以防止神经细胞受到氧化应激和其他损伤，对于帕金森病的治疗具有潜在的效果。苍术，一种野生蔬菜，属于菊科，其提取物具有神经保护作用。对苍术的进一步植物化学研究发现了八种新的（1-8）和两种已知的（9 和 10）倍半萜。基于广泛的 1D 和 2D NMR（HMQC、HMBC、（1）H-（1）H COSY 和 NOESY）光谱数据分析，确定了它们的结构，并通过 X 射线晶体学确定了 1 的结构。评估了这些倍半萜类化合物对人多巴胺能 SH-SY5Y 细胞中海洛因（CoCl2）诱导的神经元细胞死亡的神经保护活性。五种化合物表现出神经保护活性。
